摘要
目的：了解黄连和小檗碱对Ｇ６ＰＤ缺陷大鼠红细胞渗透脆性的影响，藉以推断黄连和小檗碱是否存在药物性溶血作用。方法：将黄连煎液和小檗碱溶液通过体内、外给药途径，应用于Ｇ６ＰＤ缺陷大鼠，检测其红细胞渗透脆性的变化。结果：Ｇ６ＰＤ缺陷大鼠红细胞渗透脆性仅在超大剂量给药时才有所增高。黄连和小檗碱作用相似而后者略弱。结论：以红细胞渗透脆性为指标，一般黄连剂量尚不致引起溶血。黄连和小檗碱对正常红细胞有更大的安全性。
Objective:To make clear the influence of Huanglian (Coptis chinensis) and berberine on the erythrocytic osmotic fragilitas of glucose6phosphate dehydrogenase(G6PD) deficiency in rats,so as to infer whether Huanglian and berberine have medicamentosus hemolysis effects.Method:Huanglian decoction and berberine solution are applied to the erythrocytes of G6PD deficiency in rats through external and oral administration and the erythrocytic osmotic fragilitas is measured.Result:Only at an excessively high dose can the medicines raise the erythrocytic osmotic fragilitas of G6PD deficiency in rats.Berberine and Huanglian have similar effects,but berberine is slightly weaker.Conclusion:Focus on the erythrocytic osmotic fragilitas,at a general dose,Huanglian can not cause hemolysis.Huanglian and berberine are of more safety to normal erythrocytes.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1998年第9期562-564,共3页
China Journal of Chinese Materia Medica
关键词
黄连
小檗碱
G6PD
红细胞脆性
Huanglian
combination
G6PD deficiency
rat
erythrocytic fragilitas
