摘要
目的探索小面积氯乙酸灼伤死亡与心肌损害的关系。方法对灼伤面积在４％～６％的病人及动物进行心肌酶测定，并进行动物的心肌电镜检查。结果８例小面积（≤４％）氯乙酸灼伤病人心肌酶活力均有升高，其中１例升高显著而死亡；同期测定小面积烧（烫）伤及酸碱灼伤的心肌酶均无升高；大鼠对比实验与临床结果相符，同时进行电镜检查发现心肌有超微结构改变。结论证实小面积氯乙酸灼伤可造成心肌损害。临床治疗于伤后除立即彻底冲洗创面外，还应加强心肌营养，保护心肌。
Objective To study the relation between death and myocardial injury after small area of chloroacetic acid burn(CAB). Methods The activities of myocardial enzymes were measured in patients and Wistar rats with 4%￣6% area of burn,and the ultrastructure of myocardium was observed in rats under electron microscope. Results The activities of the myocardial enzymes rose in all eight patients with CAB(≤4%),and more obviously in a case died later.Meanwhile,the myocardial enzymes remained unchanged after small areas of thermal and chemical(acid or base) burns.No difference between the results in clinic and the comparative experiment on rats was found.There were ultrastructural changes in myocardium. Conclusion The results suggested that chloroacetic acid burns of small area could result in myocardial injuries.In clinic,the first step in dealing with chloroacetic acid burns is to wash the wound as soon as possible.Besides,to enhance myocardial nutrition and to protect myocardium should also be considered.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1998年第4期207-209,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
氯乙酸
心肌酶
超微结构
化学灼伤
Burn Chloroacetic acid Myocardial enzyme Ultrastructure
