摘要
目的探讨卡托普利对慢性肺原性心脏病(肺心病)氧化应激的影响。方法将60例肺心病患者随机分为2组:对照组30例,采用常规治疗;卡托普利组30例,在常规治疗的基础上加卡托普利治疗。另选30例同期健康体检者为正常组。观察各组治疗前后心搏指数(CI)变化及血清SOD、MDA、NO水平的变化。结果对照组及卡托普利组治疗前血清SOD、NO水平均明显低于正常组,MDA高于正常组(均P<0.05);治疗3周后卡托普利组和对照组血清SOD水平较治疗前明显升高,MDA明显降低(均P<0.05);治疗12周后卡托普利组血清SOD水平显著高于对照组,MDA显著低于对照组(均P<0.05)。卡托普利组血清NO治疗后较治疗前明显升高(P<0.05);对照组血清NO治疗后轻度升高,但与治疗前比较差异无统计学意义(P>0.05)。卡托普利组和对照组治疗前CI明显低于正常组(P<0.05);治疗后CI显著升高(P<0.05)。结论卡托普利干预可提高肺心病患者血清SOD、NO含量和CI,降低血清MDA水平;SOD、NO、MDA可能参与慢性缺氧性肺动脉高压致肺心病的病理生理过程;卡托普利可能通过改善机体抗氧化能力和血管内皮细胞功能在肺心病中起重要治疗作用。
Objective The purpose of this study was to investigate the effect of captopril on oxidative stress of patients with cor pulmonale.Methods 60 patients with cor pulmonale were randomly divided into control group（30 cases）and captopril group（30 cases）,control group were treated with antibiotics and oxygen,and captopril group were treated with antibiotics、oxygen and captopril.The plasma SOD、MDA、NO levels and cardiac index（CI）of 60 patients with cor pulmonale and 30 normal population were measured before and after treatment.Results The results showed that the plasma SOD、NO level of patients with cor pulmonale were significantly lower than the normal group（P〈0.05）,while the plasma MDA level of patients with cor pulmonale was significantly higher than the normal group（〈0.05）.After treatment of 3 weeks,the plasma MDA level declined significantly in both control and captopril groups of patients（P〈0.05）,while the plasma SOD level increased significantly in both control and captopril groups of patients（P〈0.05）.After treatment of 12 weeks,the plasma MDA level in patients treated with captopril was lower than that in patients of control group（P0.05）,while the plasma SOD level in patients treated with captopril was higher than that in patients of control group（P〈0.05）.The plasma NO level in patients treated with captopril were significantly higher than before treatment,but the NO level in control groups of patients was not statistically significant compared with before treatment（P〈0.05）.CI of patients with cor pulmonale was lower than the normal group before treatment（P〈0.05）;while CI increased significicantly in both captorpril and control groups of patients after treatment（P〈0.05）.Conclusion Captopril can increase the plasma SOD、NO level and CI of patients with cor pulmonale,while decline the plasma MDA level of them.These suggest that SOD、NO、MDA may play an important role in the onset of cor pulmonale.Captopril may improve the outcomes of patients with cor pulmonale through inhibiting oxidative stress and bettering vascular endothelial function.
出处
《江西医学院学报》
2009年第9期49-51,60,共4页
Acta Academiae Medicinae Jiangxi
