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肿瘤疫苗的研究进展 被引量：3

Research progress of tumor vaccines
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摘要 随着肿瘤免疫学的不断发展,肿瘤疫苗已成为肿瘤免疫治疗研究的热点。目前,肿瘤细胞疫苗在多项临床试验中的效果较为明显,在患者体内可检测出有意义的免疫应答反应,且患者有很好的耐受性;基因疫苗在动物实验和临床试验中显示出靶向性和充分激活抗肿瘤免疫等优点;肿瘤多肽疫苗,因其化学性质稳定、易于制备、无潜在致癌性等优点,更是受到广泛关注;以现代分子生物学技术将肿瘤细胞、裂解的肿瘤细胞成分或肿瘤细胞的凋亡产物、肿瘤mRNA或DNA等修饰树突状细胞制成瘤苗,则为肿瘤治疗开辟了一种新的途径;细胞毒性T淋巴细胞表位肽疫苗通过在体内、外激发特异性CTL抗肿瘤免疫应答,部分多肽表位疫苗已进入临床Ⅰ期和Ⅱ期试验,并取得较好的疗效。本文将对这些肿瘤疫苗的作用特点、研究进展及应用现状作一综述。
作者 萨仁高娃 毕力夫 吴岩
机构地区 内蒙古医学院组织胚胎学教研室
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 北大核心 2009年第6期644-647,共4页 Chinese Journal of Cancer Biotherapy
基金 内蒙古自治区科技计划项目(No.20080502)~~
关键词 肿瘤 疫苗 免疫治疗
分类号 R730.51 [医药卫生—肿瘤] R967 [医药卫生—药理学]
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参考文献36

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二级参考文献11

共引文献6

同被引文献24

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引证文献3

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中国肿瘤生物治疗杂志
2009年 第6期

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