摘要
中性粒细胞明胶酶相关脂质运载蛋白(NGAL)是一种小分子量分泌性蛋白,属于lipocalin蛋白家族,在细胞内铁离子的转运、炎性反应、肿瘤的转移中发挥重要的作用。近年研究发现,在肾损伤后的近曲小管上皮细胞中NGAS的表达显著增强,且对肾脏有保护作用。NGAL能迅速、灵敏、特异地反映各种肾脏疾病的损伤及恢复过程,可成为检测早期肾损伤的可靠生物学指标及干预治疗的一种手段,在临床上具有广阔的应用前景。
Neutrophil gelatinase-associated lipoealin （NGAL） was a small molecular secreted protein, belonged to the lipoeahn protein family ,which played an important role in the ferri ion transport,inflammation, tumor metastasis. The recent research discovered that the expression of NGAS in the proximal tubule epitheli- al cells after kidney injury significantly enhanced,and had a protective effect on renal. The NGAS,were rapidly, sensitively, specific to reflect the different renal injury and the recovery process, which had broad clinical application as a reliable detection of early renal injury in biological markers and therapeutic intervention.
出处
《医学综述》
2010年第2期202-204,共3页
Medical Recapitulate
