摘要
目的探讨尿中阿尔茨海默病相关神经丝蛋白(AD7c-NTP)含量在阿尔茨海默病(AD)诊断中的意义。方法采用直接竞争性酶联免疫吸附测定法(ELISA),检测218例老年人,其中AD组46例、血管性痴呆组(VD组)50例、智能正常老年对照组122例尿液中AD7c-NTP含量,所有数据均经过SPSS软件进行统计学处理。结果AD组、VD组及智能正常老年对照组尿液中AD7c-NTP含量分别为33.35±1.61、18.19±1.41、18.30±1.45μg/ml,AD组明显高于其他两组,而VD组与智能正常老年对照组差异无统计学意义(P>0.05);91.4%的AD病例AD7c-NTP含量升高((22μg/ml),非AD病例中90.7%均为正常(?22μg/ml)。结论尿液中AD7c-NTP含量检测作为无创性检查,在AD诊断中具有重要的临床参考价值。
Objective To explore the value of urine AD7c-NTP assay in clinical diagnosis of Alzheimer＇ s disease （AD）. Methods The urine AD7c-NTP level was determined using Enzyme-linked immunosorbent assay in 218 elderly people,who were divided into three groups：the AD group（ n = 46）, the vascular dementia group（ VD,n = 50） and the nor- mal mental state group （ n = 122 ）. Statistical analysis was performed using SPSS 13.0. Results The urine AD7c-NTP content of the three groups were （33.35± 1.61 ）, （ 18.19 ± 1.41 ） and （ 18.30± 1.45 ） μg/ml respectively. Compared with the normal mental state group and the AD group,AD group had a significant increase of the urine ADTc-NTP level,which was positively correlated with the severity of the disease. No significant difference was found between the VD group and the normal mental state group. There were 91.4% of subjects with probable AD who had an elevated ADTc-NTP measurement （ 〉 22μg/ml）. There were 90.7% of subjects diagnosed as de？ nite non-AD who had a normal AD7c-NTP measurement （ ≤ 22μg/ml）. Conclusion Noninvasive urine AD7c-NTP test,probably a biochemical marker of AD.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2010年第1期8-11,共4页
Journal of Apoplexy and Nervous Diseases
基金
吉林省科委课题(200705464)
