摘要
目的探讨氟伐他汀治疗糖尿病肾病的疗效及其作用机制。方法将早期患者60例随机分为氟伐他汀(治疗组)和安慰剂(对照组),各30例。对照组给予糖尿病饮食,控制血糖等常规治疗;治疗组每晚加服氟伐他汀40mg。3个月后,比较两组治疗前及治疗后的尿清蛋白排出率(UAER)、血肌酐(Scr)和C反应蛋白(CRP)等指标。结果治疗组UAER、Scr和CPR下降较治疗前明显降低(P<0.01),与对照组比较UAER、CPR下降更明显。而对照组3者下降较治疗前不明显(P>0.05)。结论氟伐他汀因降低CPR的抗感染效应而减轻微量清蛋白尿和改善肾功能,该作用不依赖其降血脂效应。
Objective To explore the effect of fuvastain on early stage diabetic nephrosis, and to study its mechanism in the treatment. Methods Sixty patinents with early stage biabetic nephrosis were randomly dived into 2 groups. The control group （ n = 30） was treated with diabetic diet, controling glucose etc. The treatment group （ n = 30 ） was treaed with fuvastain （ 40mg, po, qn） on the basis of the control group. Then UAER, Scr, CRP were compared after 3 months and before treatment. Results The UAER,Scr,and CPR in the treatment groups were significantly decreased compared to before treatment,and the UAER and CPR in the treatment were significantly decreased to the control group too. Howerer, the UAER, Scr and CRP in the control groups wasn＇t significantly decreased compared to before treatment. Conclusion Because fuvastain can reduce the CRP,so the effect of resisting inflammation can lower the trace albuminueia, and improve the kidney＇s function. The effect is not dependent on the effect of fuvastain reducing lipid.
出处
《四川医学》
CAS
2010年第1期57-58,共2页
Sichuan Medical Journal
关键词
氟伐他汀
糖尿病肾病
C反应蛋白
fuvastaun
diabetic nephrosis
C-responsive protein
