摘要
目的：探讨血浆内皮素１（ＥＴ１）和降钙素基因相关肽（ＣＧＲＰ）在急性出血性脑血管病（ＡＨＣＶＤ）并发多脏器功能失常综合征（ＭＯＤＳ）发病中的作用。方法：采用放射免疫法分别测定２１例ＡＨＣＶＤ合并ＭＯＤＳ患者（ＭＯＤＳ组）、２０例ＡＨＣＶＤ患者（ＡＨＣＶＤ组）及３０例正常人（正常对照组）血浆中ＥＴ１和ＣＧＲＰ水平。结果：ＭＯＤＳ组及ＡＨＣＶＤ组血浆ＥＴ１水平明显高于正常对照组（Ｐ均＜０．０１），ＭＯＤＳ组ＥＴ１水平又明显高于ＡＨＣＶＤ组（Ｐ＜０．０１）。ＡＨＣＶＤ组血浆ＣＧＲＰ水平高于正常对照组，但无显著性差异（Ｐ＞０．０５）。而ＭＯＤＳ组血浆ＣＧＲＰ水平明显低于正常对照组，ＥＴ１／ＣＧＲＰ（Ｅ／Ｃ）比值明显高于ＡＨＣＶＤ组及正常对照组（Ｐ均＜０．０１）。结论：血浆ＥＴ１水平升高、ＣＧＲＰ水平降低、Ｅ／Ｃ比值严重失衡与ＭＯＤＳ的发生相关；
Objective:To assess the role of endothelin1 (ET1) and calcitonin gene related peptide (CGRP) in the pathogenesis of acute hemorrhagic cerebrovascular diseases (AHCVD) complicated by multiple organ dysfunction syndrome (MODS).Methods:Plasma ET1 and CGRP levels were examined in 21 AHCVD complicated by MODS (MODS group),20 AHCVD (AHCVD group),and 30 normal volunteers (NV) by radioimmunoassay.Results:Plasma ET1 levels in MODS group and AHCVD group were signif icantly higher than those in the NV (both P <0 01),and they were markedly elevated in MODS group compared to AHCVD group ( P <0 01).Plasma CGRP levels in AHCVD group were increased compared to normal controls without significant difference ( P >0 05),while they were significantly lower in MODS group than NV ( P <0 01).Moreover,ET1/CGRP ratio in MODS group was higher than those in both AHCVD group and NV (both P <0 01).Conclusions:Imbalance of ET1/CGRP might be involved in the pathogenesis of MODS,and measurement of plasma ET1 and CGRP is of clinical significance in assessment of MODS prognosis and treatment of AHCVD with CGRP.
出处
《中国危重病急救医学》
CSCD
1998年第10期630-632,共3页
Chinese Critical Care Medicine
关键词
脑血管病
出血
急性
MODS
内皮素
CGRP
acute hemorrhagic cerebrovascular diseases\ \ multiple organ dysfunction syndrome endothelin\ \ calcitonin gene related peptide
