摘要
微转移是恶性肿瘤早期即发生的行为,与预后密切相关。宫颈癌、子宫内膜癌、卵巢恶性肿瘤至今仍缺乏有效的早期诊断方法。该文就微转移的概念、与临床转移的关系、主要检测方法及临床应用价值作一综述。
出处
《安徽医药》
CAS
2010年第1期110-112,共3页
Anhui Medical and Pharmaceutical Journal
参考文献22
-
1Hermanek P,Henson DE, Hutter RVP, et al. International union against cancer. TNM supplement 1993 :a commentary on uniform use [ M ]. Berlin : Springer, 1993:7 - 14.
-
2Shimoyama M, Yamazaki T, Suda T, et al. Prognostic significance of lateral lymph node in lower rectal cancer:An immunohistochemical study with CAM 52 [ J]. Dis Colon Rectum,2003, 46:333 - 9.
-
3Benon JR, Querei della Rovere G. Sentinel lymph node in breast cancer [ J ]. Lancet, 1999,354 : 1998.
-
4Noguchi S, Hiratsuka M, Furukawa H, et al. Detection of gastric cancer in lymph nodes by amplification of Keratin 19 mRNA with reverse transcriptase-polymerase chain teaction [ J ]. Jpn J Cancer Res, 1996,87 ( 6 ) : 650 - 4.
-
5Levenback CF, Vander Zee AG, Rob L, et al. Sentinel lymph node biopsy in patients with gynecologic cancers Expert panel statement from the International Sentinel Node Society Meeting, February 21, 2008 [ J ]. Gynecol Oncol,2009,5 : 18.
-
6Thomas M Keller TM, Michel SA, Fmhlieh J, et al. USPIO-enhanced MRI for preoperative staging of gynecological pelvic tumors : prelimi- nary results[J]. Eur Radiol,2004 ,14 :937 -44.
-
7Yang XJ, Leckse Uk, Epstein J1. Can immunohistochemistry enhance the detection of micromestsses in pelvic lymph nodes frompatients with highgrade urothelial carcinoma of the bladder [ J ]. Am J Clin Pathol, 1999,112 ( 5 ) :649 - 53.
-
8Lentz SE, Muderspach LI, Felix JC, et al. Identification of micrometastases in histolngically negative lymph nodes of early-stage cervical cancer patients[ J]. Obstet Gynecol,2004,103 : 1204 - 10.
-
9Cromp C, Mclntosh MW, Urban N,et al. Ovarian cancer tumor marker behavior in asymptomatic healthy women : implications for screening[J].Cancer Epidemiol Biomarkers Prey, 2000,9 ( 10 ) : 1107 - 11.
-
10Bast JR, Klug T, John S, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer [ J ]. Obstetrical & Gynecological Survey, 1984,93 ( 3 ) : 169.
二级参考文献10
-
1Glaves D, Mayhew E. Selective therapy of metastasis. I. Quantitation of tumorigenic circulating and covert cancer cells disseminated from metastatic and nonmetastatic tumors [J]. Cancer Drug Delivery,1984,1(3) :293-302.
-
2Mori M, Mimori K, Ueo H, et al. Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease[J]. Int J Cancer,1996,68(3) :739-743.
-
3Yuan C C, Tsai L C, Hsu S C, et al. Production and characterization of a monoclonal antibody (Cx-99) against cervical carcinoma[J]. Br J Cancer,1992,65(2) :201-207.
-
4Yeh K H, Chen Y C, The S H, et al. Detection of circulating cancer cells by nested reverse transcription-polymerase chain reaction of cytokeratin-19-possible clinical significance in advanced gastric cancer[J]. Anticancer Res, 1998,18(2) : 1283- 1286.
-
5Peck K, Sher Y P, Shin J Y, et al. Detection and quantitation of circulating cancer cells in peripheral blood of lung cancer patients[J]. Cancer Res,1998,58(3) :2761-2765.
-
6Gomella L G, Raj G V, Moreno J G. Reverse transcriptise polymerase chain reaction for prostate specific antigen in the management of prostate cancer[J]. J Urol,1997,158(3):326-337.
-
7Yuan C C, WangPH, Heung-TatNG, etal. DetectingCytokeratin 19 mRNA in the peripheral blood cells of cervical cancer patients and its clinical-pathological correlation[J]. Gynecol Oncol, 2002,85 (2) : 148- 153.
-
8刘永昌,梁小波,孙俊宁,刘清俊,付梅琴.结直肠癌向肝微转移的观察[J].中国肿瘤临床,2000,27(1):35-37. 被引量:25
-
9邱林,丛笑,贾立群,张远春,王在永,赵武述.肿瘤细胞株和癌组织角蛋白19、20mRNA表达及临床意义[J].中华肿瘤杂志,2000,22(1):32-35. 被引量:25
-
10冯玉梅,郝希山,于泳,王立梅,李希.CK19作为微转移癌检测基因标志的假基因干扰及解决方法[J].中华肿瘤杂志,2001,23(4):330-331. 被引量:24
共引文献7
-
1刘蕴霞.细胞化学标记在鉴别胸腹水恶性肿瘤细胞来源中的应用初探[J].实用全科医学,2006,4(1):97-98.
-
2高玉民,崔正言.妇科恶性肿瘤骨髓微转移研究进展[J].实用妇产科杂志,2006,22(4):207-209.
-
3刘兆董,江忠清,戴丽玉.宫颈癌微转移研究进展[J].国际检验医学杂志,2008,29(6):525-527. 被引量:4
-
4桂霞,赵星,丁钱超,黄艳春.早期宫颈癌患者外周血中CK19 mRNA的检测意义[J].新疆医学,2012,42(8):47-51.
-
5杨光琼,杨沛.循环肿瘤细胞的研究进展及其在宫颈癌的研究前景[J].华西医学,2014,29(2):374-376.
-
6孙俊宁,常竹鲜,李秀芳,刘永昌.在癌基因研究中应用巢式RT-PCR[J].山西医科大学学报,2001,32(3):202-204.
-
7孙俊宁,刘永昌,梁小波,刘清俊,常竹鲜,何霭.巢式RT-PCR检测大肠癌患者门静脉血中癌细胞[J].山西临床医药,2001,10(8):579-580.
同被引文献33
-
1初培国.细胞角蛋白染色在肿瘤诊断中的应用[J].中华病理学杂志,2004,33(3):273-276. 被引量:39
-
2朱勇,王业皇.肠癌微转移的检测及意义[J].结直肠肛门外科,2006,12(1):57-59. 被引量:1
-
3陈莹莹,易莉莎,侯敏敏,郄明蓉.恶性肿瘤微转移的研究进展[J].中华妇幼临床医学杂志(电子版),2007,3(5):292-295. 被引量:3
-
4Patel NS,Dobbie MS,Rochester M,et al.Up-regulation of endothelial delta-like-4 expression correlates with vessel maturation in bladder cancer[J].Clin Cancer Res,2006,12(16):4836-4844.
-
5Patel NS,Li JL,Generali D,et al.Up-regulation of delta-like-4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function[J].Cancer Res,2005,65(19):8690-8697.
-
6Shutter JR,Scully S,Fan Wei,et al.Dl14,a novel Notch ligand expressed in arterial endothelium[J].Genes Dev,2010,14(11):1313-1318.
-
7Krebs LT,Xue Yingzi,Norton CR,et al.Notch signaling is essential for vascular morphogenesis in mice[J].Genes Dev,2000,14(11):1343-1352.
-
8Villa N,Walker L,Lindsell CE.Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels[J].Mech Dev,2001,108(1/2):161-164.
-
9Claxton S,Fruttiger M.Periodic Delta-like 4 expression in developing retinal arteries[J].Gene Expr Patterns,2004,5(1):123-127.
-
10Artavanis-Tsakonas S.Notch signaling:cell fate control and signal integration in development[J].Science,1999,284(5415):770-776.
引证文献2
-
1桑明,王燕,王珺,孙晓东,罗超,龚坚,彭新春,余明华.阻断Notch信号途径能有效抑制A549细胞增殖[J].安徽医药,2012,16(7):924-927. 被引量:2
-
2罗婧,张三元.细胞角蛋白19在肿瘤微转移中的研究进展[J].世界最新医学信息文摘,2018,18(34):112-114. 被引量:3
二级引证文献5
-
1罗翠莲,文庆莲.肿瘤抗血管生成治疗耐药分子机制研究进展[J].肿瘤预防与治疗,2014,27(1):33-38. 被引量:4
-
2孙晓东,王珺,王燕,田宗文.DLL4/Notch信号途径对A549细胞VEGF表达的影响[J].现代医药卫生,2014,30(7):963-965.
-
3韩智,乔永宏,田垒,李罡.肝脓肿患者细胞角蛋白-19表达及其调控肝细胞DNA损伤的机制研究[J].肝胆外科杂志,2020,28(5):388-392.
-
4高旭,王腾祺,贾立周.胸苷激酶1和细胞角蛋白19在胃肠道恶性肿瘤中应用的研究进展[J].中国医药,2022,17(5):779-783. 被引量:7
-
5张晨静,杨勇莉.肿瘤微转移的相关研究及AE1/AE3在其中的价值[J].临床个性化医学,2024,3(2):436-441.
-
1崔友红,卢玉波,杨宏英.宫颈癌微转移的研究现状[J].现代肿瘤医学,2008,16(11):1998-2001. 被引量:4
-
2许超,王强,蔡清萍,颜荣林,李晓凯,陈学云.CXCR3在结直肠癌组织中的表达及临床意义[J].中华实验外科杂志,2008,25(5):609-611. 被引量:4
-
3吴春秀,魏向群.宫颈癌微转移的研究进展[J].现代肿瘤医学,2014,22(7):1718-1720. 被引量:3
-
4苏丽萍,张进平,陈晋,王缨,熊思东.CXCR4在肺癌组织中的表达及临床意义[J].中国癌症杂志,2005,15(2):97-100. 被引量:23
-
5黄蓓,武忠弼,阮幼冰.人肝癌组织nm23的表达及其与转移的关系[J].临床与实验病理学杂志,1997,13(1):25-26. 被引量:8
-
6董娜娜,段晓峰,张倜,李慧锴,周洪渊,李强.103例肝内胆管癌临床病理及诊治分析[J].中国肿瘤临床,2012,29(6):340-342. 被引量:13
-
7崔涛,朱祖安,刘莹,杨雪梅,孔庆兖.NF-κB、c-erbB-2和VEGF-C在乳腺癌组织中的表达与临床转移、分期间的关系[J].诊断病理学杂志,2009,16(1):58-59. 被引量:3
-
8孙颖,刘国炳,余艳红.盆腔淋巴结HPV-DNA检出率与早期宫颈癌临床转移的关系[J].南方医科大学学报,2008,28(5):796-798. 被引量:10
-
9李志华,陈汝福,宋先让,衣龙海.原发性肝癌介入治疗前后血清血管内皮生长因子的变化及其意义[J].中国误诊学杂志,2003,3(7):980-982. 被引量:5
-
10李进贤,薛涣洲,陈汝福,陈积圣,李志花.原发性肝癌介入治疗前后血清血管内皮生长因子的变化[J].中华实验外科杂志,2002,19(5):417-418. 被引量:11