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类风湿关节炎患者外周血淋巴细胞计数与感染的相关性研究 被引量:2

Correlation Analysis of Peripheral Blood Lymphocyte Count and Infection in patients with Rheumatoid Arthritis
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摘要 目的探讨外周血淋巴细胞计数与RA患者感染的相关性,为RA患者合并感染的防治提供临床依据。方法分析嘉兴市第一医院2004年1月-2008年12月住院RA患者319例,其中,男性75例,女性244例,平均年龄57.1±13.1(20~88)岁;平均病程10.5±8.0(3个月~40年)年。感染组104例,非感染组215例。检测项目包括外周血白细胞、淋巴细胞、中性粒细胞计数、血红蛋白、血小板、红细胞沉降率、C-反应蛋白、类风湿因子和淋巴细胞亚群。计量资料以均数±标准差表示,组间比较采用t检验。结果与非感染组RA患者比较,感染组患者的年龄大、男性多、病程长、ESR快、CRP和中性粒细胞增多以及血红蛋白、淋巴细胞计数减低差异有统计学意义,其中,淋巴细胞计数与感染呈显著性负相关(r=0.701,P<0.01);而类风湿因子、外周血白细胞、血小板在感染组与非感染组之间差异无统计学意义。结论RA患者感染的危险因素包括年龄大、男性、病程长、ESR快、CRP升高、中性粒细胞增多、贫血,外周血淋巴细胞计数与感染呈显著性负相关。 Objective To evaluate the correlation of peripheral blood lymphocyte counts and infection and provide clinical basis for the prevention and treatment of infection in patients with RA.Methods 319 cases of hospitalized RA patients from January 2004 to December 2008 including 75 cases of male and female 244 cases,an average age of 57.1±13.1(20 to 88) years,average duration of 10.5±8.0(3 months to 40 years) years.104 cases and 215 cases were located in infection group and non-infection group,respectively.Test items were included peripheral blood leukocytes,lymphocytes,neutrophil count,hemoglobin,platelets,erythrocyte sedimentation rate,reactive protein-C,rheumatoid factor,and lymphocyte subsets.Measurement data was expressed as mean±SD and was compared between the two groups by student t test.Results Compared to non-infection group of patients with RA,the risk factors of infection were older,male,longer disease course,ESR,CRP and neutrophils elevation,hemoglobin and lymphocyte count reduction,in which total lymphocytes counts and infection was significant negative correlation(r=0.701,P0.01);while rheumatoid factor,white blood cells,platelets were not significantly different between infection group and non-infection between groups.Conclusion Risk factors for infection in RA patients included older,male,longer disease duration,fast ESR,increased CRP and neutrophils count and anemia.Peripheral blood total lymphocyte count was significantly negatively correlated with infection.
出处 《中华全科医学》 2010年第2期185-186,共2页 Chinese Journal of General Practice
关键词 类风湿关节炎 淋巴细胞计数 感染 危险因素 Rheumatoid arthritis Lymphocyte count Infection Risk factors
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