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LKB1在腺癌中研究进展 被引量：3

Research Progress of Expression of LKB1 in Adenocarcinomas
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摘要 目的探讨LKB1与腺癌的发生发展的关系。方法搜集整理1999-2009年国内外发表的相关文献,对LKB1结构功能、抑癌机理及其在不同腺癌组织中的表达情况进行总结分析,并对LKB1与腺癌发生、发展及转移之间的关系进行回顾性分析。结果LKB1的突变或缺失表达与众多腺癌的发生发展成正相关,如肺腺癌、乳腺癌和胃腺癌等。在肺腺癌的脑转移过程中,LKB1的缺失表达起积极作用。结论通过对LKB1基因的修复,可以增加腺癌细胞凋亡,从而为腺癌早期诊断及治疗提供新的思路和依据。 Objective To explore the relationship between LKB1 and incidence of adenocarcinomas.Methods To collect and sort the related literatures published at home and abroad from 1999 to 2009,and analyze the structure and function,tumor suppression mechanism,expression in different adenocarcinoma tissues of LKB1 gene.Results The missing or mutation of LKB1 was closely related to the occurrence and development of many adenocarcinomas,such as lung adenocarcinoma,breast cancer,gastric adenocarcinoma,etc.The missing or mutation of LKB1 also played an important part in brain metastasis from lung Adenocarcinomas.Conclusion To repair LKB1 can increase the apotosis of cell in Adenocarcinomas.The study on LKB1 can provide a new idea and more evidences for the early clinic diagnosis and treatment of adenocarcinomas.
作者 程忠强 詹晓东
机构地区 安徽省蚌埠医学院第一附属医院耳鼻喉头颈外科
出处 《中华全科医学》 2010年第2期224-225,共2页 Chinese Journal of General Practice
关键词 抑癌基因 LKB1 腺癌 Tumor suppressor gene LKB1 Adenocarcinomas
分类号 R730.261.1 [医药卫生—肿瘤] R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献20

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二级参考文献93

  • 1丁新民,徐勤枝,周平坤.LKB1基因功能及与肿瘤关系研究进展[J].国外医学（肿瘤学分册）,2004,31(10):723-726. 被引量：9
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共引文献31

同被引文献37

  • 1夏雷,莫伏根,李刚,徐新宇.胃癌中HER-2和HER-3的表达及临床意义[J].实用老年医学,2013,27(11):903-907. 被引量：5
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  • 6Katajisto P, Vaahtomeri K, Makela TP, et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis [ J ]. Nat Genet, 2008, 40 ( 4 ) : 455-459.
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引证文献3

二级引证文献2

中华全科医学
2010年 第2期

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