期刊文献+

帕瑞昔布用于腹腔镜手术七氟醚全麻苏醒期躁动及不良反应的临床观察 被引量:15

CLINICAL EXPERIENCE OF PARECOXIB AS A SUPPRESSANT OF AGITATION AFTER LAPAROSCOPIC OPERATION WITH SEVOFLURANE GENERAL ANESTHESIA AND OBSERVING THE UNTOWARD EFFECTS
下载PDF
导出
摘要 目的探讨帕瑞昔布对腹腔镜手术七氟醚全麻苏醒期躁动及其不良反应的效果。方法择期全麻下腹腔镜手术90例,ASAⅠ-Ⅱ级及健康成人,采用随机双盲对照方法,将患者分成三组,手术结束前30分钟分别静脉注射帕瑞昔布40mg(实验组T组),芬太尼1μg/kg(对照组F组),等体积生理盐水组(空白对照组C组)。记录患者拔管前5分钟,拔管时,拔管后5分钟的心率、平均动脉压;观察各组术后躁动发生率、清醒情况、拔管时间和术后不良反应的发生率。结果①与C组相比,T组和F组拔管后躁动发生率明显减少(p〈0.05);②C组患者与T组和F组相比,拔管后5分钟心率和平均动脉压明显增高(P〈0.05);③T组拔管时间和苏醒时间与C组相当,均明显少于F组(p〈0.05);④C组恶心、呕吐发生率及镇痛需求明显高于T组(P〈0.05)。结论健康成人静脉注射40mg帕瑞昔布可以减少腹腔镜手术七氟醚全麻术后躁动的发生率,不明显延长拔管时间和苏醒时间,不增加术后不良反应发生率。 Objective To investigate the effects of the parecoxib administration on agitation after laparoscopie operation with sevoflurane general anesthesia and observing the untoward effects. Methods A total of 90 patients aged from 18 years to 60 years in good health ( ASA physical status Ⅰ - Ⅱ ) undergoing selective laparoseopie surgery were randomly and double blindly divided into three groups. The patients were induced with midazolam, fengtanyl, vecuronium and propofol, and maintained with 2% -5% sevoflurane and oxygen. In group T, parecoxib 40 mg were administrated 30 minutes before the end of operation, and fentany 1 ug/kg in group F, and in group C was given an equal volume of NS. The heart rate (HR) ,mean arterial blood pressure (MAP) were assessed during the anesthesia. The extubation time, waking time, postoperative agitation, nausea and vomiting were observed and recorded. Results The agitation was remarkably suppressed in group T and group F than group C. And there was a significant difference in mean heart rate and mean arterial blood pressure in group C compared with group T and F. And the extubation time and waking time were almost the same in group T and group C, both shorter than that in group F. The rate of nausea and vomiting did not increase in group T. Conclusion It is safe and feasible to give pareeoxib 40mg to reduce agitation and untoward effect after laparoseopic operation with sevoflurane general anaesthesia.
机构地区 东莞康华医院
出处 《现代医院》 2010年第1期22-25,共4页 Modern Hospitals
关键词 帕瑞昔布 七氟醚 躁动 腹腔镜手术 Parecoxib, Sevoflurane, Agitation, Laparoscopic
  • 相关文献

参考文献7

  • 1CUNNIFFE M G, MCANENA O J, DAR M A, et al. A prospective randomized trial of intraopective bupivaeaine irrigation for management of should - tip pain following taparoscopy [ J ]. Am J Surg, 1998,176:258 - 261.
  • 2GLINKIN J L, FAZI L M, CUY R M, et al. Use of intranasal fentanyl in children undergoing myringotomy and tube placement during halothane and sevoflurane anesthesia[J]. Anesthesiology,2000,93 (6) : 1378 - 1383.
  • 3WELDON B C, BELL M, CRADDOCK T. The effect of caudal analgesia on emergence agitation in children after sevoflurane versus halothane anesthesia [ J ]. Anesth Analg,2004,98 ( 2 ) :321 - 326.
  • 4尚宇,周凯泉,范杰,梁宏,田立刚,赵璠.氟比洛芬酯超前镇痛在腹腔镜手术中的应用[J].医药导报,2007,26(9):1011-1012. 被引量:11
  • 5黎祖荣,王明德,魏佳,刘宇.麻醉恢复室患者躁动的原因及相关因素分析[J].临床麻醉学杂志,2009,25(6):536-536. 被引量:68
  • 6LEMAN J,DAVIS P J,WELBRON L G,et al. Induction, recovery, and safcfy characteristics of scvoflurane in children underoing ambulatory surgery [ J ]. Anesthesiology, 1996,84 : 1332 - 1340.
  • 7TALLCY J J, BERTENSHAW S R, BROWN D L, et al. N - [ [ ( 5 - methyl - 3 - phenylisoxazol - 4 - yl) phenyl ] sulfonyl ] propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX - 2 for parenteral administration[ J]. Med Chem,2000,43 : 1661 - 1663.

二级参考文献7

  • 1段砺瑕,李晓玲.氟比洛芬酯注射液的药理作用及临床应用[J].中国新药杂志,2004,13(9):851-852. 被引量:602
  • 2OHMUKAI O.Lipo-NSAID preparation[J].Adv Drug Deli Rev,1996,20(2):203 -207.
  • 3PIER A,BENEDIC M,MANN B,et al.Postlaparoscopic pain syndrome results of a prospective randomized study[J].Chirurg,1994,65(3):200 -204.
  • 4GOTTSCHALK A,SMITH D S.New concepts in acute pain therapy:preemptive analgesia[J].Am Fam Physician,2001,63 (12):1979 -1984.
  • 5东野正男,小西与志昭,小屿博.LFP83单回及び连续静脉内投与时のと卜血中浓度推移及び代谢[J].基础と临床,1992,26(1):83-97.
  • 6PERTTUNEN K,NILSSON E,KAISO E.I.v.diclofenac and ketorolac for pain after thoracoscopic surgery[J].Br J Anaesth,1999,82(2):221 -227.
  • 7THWAITES B K,NIGUS D B,BOUSKA G W,et al.Intravenous of ketotolac tromethamine does not worsen platelet function during knee arthroscopy under general anesthesia[J].Anesth Analg,1995,81 (1):119-122.

共引文献77

同被引文献132

引证文献15

二级引证文献109

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部