摘要
为了提高光动力疗法（ＰＤＴ）的治癌效果，应用ＰＤＴ与瘤内注射氟尿嘧啶（５－Ｆｕ）治疗小鼠前胃癌移植瘤。治疗后各组移植瘤细胞ＤＮＡ含量和标记指数（ＬＩ）均较治疗前明显减少，而联合治疗组的减少较单纯ＰＤＴ或瘤内注射５－Ｆｕ组更为显著。又应用ＰＤＴ治疗进展期食管、贲门癌患者８０例，并对其中４０例联合应用内镜下局部注射５－Ｆｕ。结果：ＰＤＴ组的近期显效率为２２．５％（９／４０），联合治疗组显效率为４５．０％（１８／４０），高于ＰＤＴ组（Ｐ＜０．０５）。病例随访１２月～１８月，联合治疗组的平均生存期（３７４天）较ＰＤＴ组（２６６天）延长（Ｐ＜０．０１）。认为ＰＤＴ与局部注射５－Ｆｕ联合治疗上消化道癌，能协同提高ＰＤＴ的治疗效果。
In order to improve local therapeutic effect of PDT, transplanted mouse forestomach carcinomas were treated by combination with local chemotherapy. DNA contents and labelling index(LI) of tumor cells were determined at 1,6, and 24 hours after treatment. In the group with combined treatment, DNA contents and LI of tumor cells were significantly lower than that in the groups PDT alone or 5 Fu alone (P<0 01). Of 80 patients with advanced esophagocardiac cancers treated with PDT, 40 were treated by combination with endoscopic local chemotherapy. The PDT was carried out at 24,48, and 72 h after intravenous injection of hematoporphyrin derivative (HpD) 3 mg/kg-5 mg/kg. The entire tumor was irradiated with 630 nm copper vapour pumped dye laser. In the combined treatemnt group, besides PDT, 250 mg-500 mg of 5 Fu was locally injected prior to each irradiation, In the PDT group, CR+SR occurred in 9 out of 40 cases(22.5%). In the combined treatment group CR+SR occurred in 18 out of 40 cases (45.0%). The rate of significant remission in combined treatment group was significantly higher than that in PDT group (P<0 05). The patients were followed up for 12-18 months, the mean survival time of the combined treatment group was longer than that of PDT group (374 days vs. 266 days, P<0 01). These results indicate that PDT combined with local injection of 5 Fu is a safe and effective treatment for advanced esophagocardiac cancers, and may improve the therapeutic effect.
出处
《中国激光医学杂志》
CAS
CSCD
1998年第4期198-201,共4页
Chinese Journal of Laser Medicine & Surgery
关键词
光动力疗法
局部化疗
上消化道癌
Photodynamic therapy, Local chemotherapy, Upper digestive tract cancer
