摘要
目的提高妊娠中期唐氏综合征(Down’s Syndrome,DS)的筛查率,预防和减少唐氏征儿的出生。方法对本院363例妊娠14～20周孕妇进行血清甲胎蛋白(AFP)和游离绒毛膜促性腺激素(free-β-HCG)检测,唐氏综合征高风险切割值为1∶270,对高风险及临界风险者建议进行产前诊断。结果筛查363例中期孕妇,检出25例DS高风险孕妇,阳性率为6.9%,有12例接受了羊水穿刺检查。发现胎儿染色体异常2例,异常检出率为16.67%。筛查神经管缺陷(Nervous tube defect,NTD)高危5例,阳性率为1.38%,在高危孕妇中查B超发现异常胎儿1例。结论孕中期母血清联合检测AFP和F-β-HCG,本方法简便易行,无创伤性,便于在孕妇中进行大规模的筛查,对发现胎儿先天缺陷有效可行。
Objective To improve the medium-term pregnancy with Down＇ s syndrome screening rate in order to prevent and decrease of the birth rate of Down＇ s syndrome infant. Methods To detect the blood level of AFP and free-β-HCG of 363 pregnancy woment between 14 - 20 weeks of our hospital. Cuting numerical value is 1：270. We recommend those who with high DS risk to do the amnitic fluid examination. Result 363 pregnant women accepted antenatal screening. 25 cases of them were detected at high risk with Downs syn- drome, and positive rate was 6. 9% . Of 12 cases diagnosed by amniocentesis ,2 cases with fetal abnormal chro- mosome. The detectable rate was 16. 67% ; 5 cases at high risk of Downs syndrome, the positive rate was 1.38%. In the high-risk pregnant women, 1 cases with abnormal fetal were found by ultrasonic B. Conclusion AFP combined with F-β-HCG is the effective method, which is simple, noninvasive, easy to carry out large- scale in pregnant women in the screening, and can reduce the birth rate of fetal malformation.
出处
《中国实用医药》
2010年第1期28-29,共2页
China Practical Medicine
