摘要
目的分析老年2型糖尿病患者血清脂联素水平和早期动脉粥样硬化的关系。方法将55例老年2型糖尿病患者根据颈动脉内膜中层厚度(carotid intima-media thickness,CIMT)进行分组,29例CIMT≤0.9mm的2型糖尿病患者为非动脉粥样硬化组,另外26例CIMT>0.9mm或发现动脉斑块的2型糖尿病患者为动脉粥样硬化组,并配对选取25例非糖尿病的健康者为对照组。同时收集入选者的临床资料,包括年龄、性别、体质量指数(BMI)、踝臂指数(ABI)、糖化血红蛋白(HbA1c)、血糖、空腹血脂以及胰岛素等生化指标,并计算稳态模型(HomaModel)的胰岛素抵抗指数HomaIR=(FINS×FPG)/22.5,取其自然对数值;用酶联免疫法测定入选者的血清脂联素。结果(1)动脉粥样硬化组的血清脂联素显著低于非动脉粥样硬化组及对照组。(2)相关性研究显示脂联素与血糖、HbA1c、高敏C反应蛋白(hs-CRP)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、CIMT负相关(r=-0.30,r=-0.32,r=-0.23,r=-0.66,r=-0.83,r=-0.63,r=-0.77,r=-0.33;P<0.01),而与高密度脂蛋白胆固醇(HDL-C)、踝臂指数正相关(r=0.89,r=0.35;P<0.01)。(3)多元逐步回归分析显示低密度脂蛋白胆固醇与高密度脂蛋白胆固醇是影响血清脂联素水平的独立因素。结论在老年2型糖尿病患者中,血清脂联素降低与动脉粥样硬化密切相关。
Objective To study the correlation between serum adiponectin and early atherosclerosis in aged patients with type 2 diabetes mellitus （DM）. Methods Fifty-five aged patients with type 2 DM, enrolled in this study, were divided into non-atherosclerosis group with their carotid intima-media thickness （CIMT） ≤ 0.9 mm （ n = 29） and atherosclerosis group with their CIMT 〉 0.9 mm （n = 26）. Twenty-five healthy individuals served as a control group. Clinical data including age, sex, BMI, ABI, HbAlc ,fasting glucose and insulin were collected. Insulin resistance index in Homa model was calculated following the equation： Homa IR = FINS x FPG）/22.5. Serum adiponectin level was measured by ELISA. Results The serum adiponectin level was significantly lower in atherosclerosis group than in non-atherosclerosis and control groups （P 〈0. 01 ）. The adiponectin level was negatively correlated with the levels of glucose, HbAlc, hs-CRP, TC, LDL-C, TG and CIMT but positively correlated with HDL-C and ABI （P 〈 0. 05 ）. Multiple stepwise regression analysis showed that LDL-C and HDL-C were the independent factors influencing the serum adiponectin level. Conclusion Low serum adiponectin level is correlated with atherosclerosis in aged type 2 DM patients.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2010年第4期372-375,共4页
Journal of Third Military Medical University
基金
国家自然科学基金(30771038
30570744
30370670)~~
