摘要
目的探讨YKL-40、Survivin在前列腺癌中的表达及与临床病理学参数的关系,评价二者对判断患者预后的价值。方法采用免a疫组织化学EnVision法检测56例前列腺癌中YKL-40、Survivin的表达情况。用Kaplan-Meier法分析生存曲线,多变量Cox比例风险回归模型筛选影响患者生存的独立预后因素。结果56例前列腺癌中,YKL-40阳性表达41例(73%),Survivin阳性表达45例(80%),二者表达呈正相关,共同阳性表达34例(61%);与Gleason评分及骨转移有关(P<0.05)。YKL-40阳性、Survivin阳性、共同阳性表达及Gleason积分高的患者术后生存时间明显缩短,Cox多因素分析表明YKL-40与Gleason评分是影响患者生存的独立预后因素。结论YKL-40、Survivin在前列腺癌中普遍高表达,与Gleason评分、临床分期、骨转移及患者术后生存有关,有助于判断前列腺癌的恶性程度、监测患者预后。
Objective To explore the correlation between expression of YKL-40 and Survivin and the clinicopathology in prostate carcinoma, and to evaluate the value of these two aspects in prognosis estimation. Methods The expression of YKL-40 and Survivin was detected immunohistochemically in 56 cases of prostate carcinoma. Kaplan- Meier and multivariate Cox proportional hazards regression model analysis were applied to compare the survival curves and screen the independent prognosis factors respectively. Results Of 56 cases of prostate carcinoma, YKL-40 and survivin were expressed in 73% and 80%, respectively, positively correlated with each other, and were associated with Gleason＇s score and bone metastasis （P〈0.05）. Thirty-four cases （61%） were found to be double-positive for YKL-40 and Survivin expressions. Patients with positive expression of YKL-40 and/or Survivin and high Gleason＇s score experienced significantly shorter length of survival. Cox regression indicated that YKL-40 and Gleason grade were independent prognostic factors for survival in prostate carcinoma. Conclusion The expression of YKL-40 and Survivin was found to be frequently elevated in prostate carcinoma, and were linked to Gleason＇s score, clinical stage, bone metastasis and postoperative survival. The biomarkers may be useful to evaluate the degree of malignancy and to monitor the prognosis of prostate carcinoma.
出处
《中国药物与临床》
CAS
2010年第2期144-146,I0001,共4页
Chinese Remedies & Clinics
