摘要
Calcium sensing receptors (CaSR) is a member of super-family of G-protein coupling receptors. This review first introduced the concept,construction features,distribution,functions,decision methods,moderators,genetic locus of CaSR and its relationship with some diseases concisely. Then this article described the investigation progress of CaSR in cardiovascular system intensively,including the expression pattern,role and signal pathways of CaSR in rat myocardium in normal,ischemia-reperfusion injury,apoptosis and cardiac hypertrophy; the role and mechanism of CaSR in calcium homostasis regulation of rat myocardium,endoplasmic reticulum (ER) stress and cardiac ischemic preconditioning and postconditioning. The metabolism rule,physiological significance and pathological action of polyamine in cardiac cells; the increase of CaSR expression in cardiac tissue of artherosclerosic rat and its effect on sensitivity to acute myocardial infarction are also discussed. In the end,the research perspective of CaSR in cardiovascular system was anticipated.
Calcium sensing receptors （CaSR） is a member of super - family of G - protein coupling receptors. This review first introduced the concept, construction features, distribution, functions, decision methods, moderators, genetic locus of CaSR and its relationship with some diseases concisely. Then this article described the investigation progress of CaSR in cardiovascular system intensively, including the expression pattern, role and signal pathways of CaSR in rat myocardium in normal, ischemia- reperfusion injury, apoptosis and cardiac hypertrophy; the role and mechanism of CaSR in calcium homostasis regulation of rat myocardium, endoplasmic reticulum （ER） stress and cardiac ischemic preconditioning and postconditioning. The metabolism rule, physiological significance and pathological action of polyamine in cardiac ceils ; the increase of CaSR expression in cardiac tissue of artherosclerosic rat and its effect on sensitivity to acute myocardial infarction are also discussed. In the end, the research perspective of CaSR in cardiovascular system was anticipated.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第2期409-413,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.30370577
No.30470688
No.30700288
No.30770878
No.30871012)
教育部高校博士点基金资助项目(No.20070226012)
关键词
钙敏感受体
心血管系统
再灌注损伤
内质网应激
心肌肥大
Calcium sensing receptor
Cardiovascular system
Reperfusion injury
Endoplasmic reticulum stress
Myocardial hypertrophy
