摘要
目的观察一种新型复方胍类消毒剂杀菌效果及其毒性。方法采用悬液定量杀菌试验和动物试验方法,对该消毒剂杀菌效果及其毒性进行了实验室检测。结果以含聚合单胍盐聚环己胍和聚[2-(2-乙氧基)-乙氧基乙酯〕胍5000 mg/L的该复方消毒剂原液作用0.5 min,对悬液内大肠杆菌、金黄色葡萄球菌和铜绿假单胞菌的平均杀灭对数值均>5.00;作用1 min,对白色念珠菌平均杀灭对数值>4.00。该复方消毒剂对小鼠急性经口LD50>5000 mg/kg体重,属实际无毒。该消毒剂原液对动物完整皮肤、破损皮肤和眼睛黏膜均无刺激性。该消毒剂对小鼠骨髓嗜多染红细胞无致微核作用。结论该复方胍类消毒剂对细菌繁殖体和真菌具有较好的杀灭效果,使用安全。
Objective To observe the germicidal efficacy and toxicity of a new - type compound guanidine disinfectant. Methods Suspension quantilative germicidal test and animal experiments were performed to observe the germicidal efficacy and toxicity of the disinfectant. Results The killing logarithm values of Escherichia colt, Staphylococcus aureus and Pseudomonas aeruginosa exposed to the stock solution of the compound disinfectant containing poly - hexanaphthene - guanidine and poly - [2 - （2 -ethoxy） -ethoxyethyl guanidine chloride] 5000 mg/L for 0.5 rain were 〉5.00. The kill- ing logarithm value of Candida albicans exposed for 1 min was 〉 4.00. The mouse acute oral toxicity test for this disinfectant indicated that the oral LD50 〉 5000 mg/kg · bw which belonged to actually non - toxic class. The stock solution of the disinfectant had no irritating effect on animal intact or damaged skin and eye mucosa. It did not induce micro - nucleus formation in polychromatic erythrocytes of mouse bone marrow. Conclusions The compound guanidine disinfectant has good efficacy in killing vegetative forms of bacteria and fungi and can be used safely.
出处
《中国消毒学杂志》
CAS
2010年第1期42-44,共3页
Chinese Journal of Disinfection
关键词
复方胍类消毒剂
杀菌效果
毒性
compound guanidine disinfectant
germicidal efficacy
toxicity
