摘要
目前，外科手术仍然是早期肺癌的首选治疗方式，但部分早期肺癌患者诊断时因高龄、心肺功能差等原因不能耐受手术切除。这部分患者大多数接受胸部放射治疗，但肿瘤局部控制率和长期生存率均不理想。近年来，影像引导射频消融技术开始应用于早期肺癌的治疗。多个临床研究显示射频消融治疗肺癌具有良好的安全性，创伤小，并发症少，恢复快，长期治疗效果令人鼓舞。但仍需要进行大规模、多中心的临床研究以确定CT引导射频消融对早期肺癌的治疗效果。
Surgical resection remains the cornerstone of therapy for early stage lung cancer. Five-year survival rates are reported as high as 92 % for stage I non-small cell lung cancer （NSCLC）. However, many patients presenting with resectable early stage disease are unable to tolerate pulmonary resection, even sublobular resection, because of compromised cardiopulmonary functions or other comorhidities. Traditionally, patients deemed medically inoperable have been treated by external-beam radiation. But the results were poor with a mean survival of 20 months and a 5-years survival rate of 12 %. In this scenario, we need to develop other non-surgical local therapies. One of these was image-guided percutaneous radiofrequency ablation（RFA）. Many clinical trials show that RFA for lung tumors is a minimally invasive, feasible and safe technique with minor mortality and morbidity. Moreover, its efficacy seems to be promising, even in the long-term follow-up. Further experiences and comparison with other emerging minimally invasive local treatments are required to determine its rote in the treatment of medically inoperable early stage NSCLC.
出处
《肿瘤研究与临床》
CAS
2010年第1期19-22,共4页
Cancer Research and Clinic
关键词
肺肿瘤
导管消融术
微侵袭技术
Lung neoplasms
Catheter ablation
Minimally invasive procedure
