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子宫内膜癌Survivin蛋白和COX-2的表达及相关性研究

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摘要 目的:探讨子宫内膜癌组织中Survivin蛋白和COX-2的表达及其在子宫内膜癌发生、浸润和转移中的作用。方法:应用免疫组织化学法检测子宫内膜癌组织、不典型增生子宫内膜和正常子宫内膜组织中Survivin蛋白和COX-2的表达。结果:Survivin蛋白在子宫内膜癌中的阳性率高于正常子宫内膜和不典型增生子宫内膜,差异有显著性(P<0.05);COX-2在子宫内膜癌中的阳性率高于正常子宫内膜和不典型增生子宫内膜,差异有显著性(P<0.05)。在子宫内膜癌组织中,随组织学病理分级的增加、手术临床分期的进展、肌层浸润程度的加深,Survivin蛋白和COX-2表达阳性率逐渐上升,差异有显著性(P<0.05)。结论:Survivin蛋白、COX-2高表达与子宫内膜癌的发生、发展过程相关,联合检测可为子宫内膜癌的早期诊治及预后判断提供可能的理论依据。
作者 张红 史惠荣
出处 《中国民康医学》 2010年第2期109-110,共2页 Medical Journal of Chinese People’s Health
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参考文献12

  • 1杨丹,韩立敏.1969-2003年子宫内膜癌发病率及发病因素分析[J].复旦学报(医学版),2005,32(4):479-480. 被引量:33
  • 2Ambrosini G, Adida C, Ahieri DC. A novel anti - apoptosis gene, Survivin,expressed in cancer and lymphoma[J]. Nat Med, 1997, 3:917 - 921.
  • 3Shin S, Sung B J, Cho YS, et al. An anti- apoptotic protein human Survivin is a direct inhibitor of caspase - 3 and - 7[J]. Biochemistry,2001,40:1117 - 1123.
  • 4Shin S,Sung B.I,Cho YS et al. An anti- apoptotio protein human Survivin is a direct inhibitor of easpase- 3 and - 7[J]. Biochemisry, 2001,40(4) : 1117.
  • 5Falleni M, Pellegrini C, Marchetti A, et al. Survivin gene expression in early - stagenon - small cell lung cancer[J].J Pathool, 2003,200(5) :620.
  • 6Takai N, Miyazaki T, Nishide M, et al. Survivin expression correlates with clinical stage histological grade invasive behavior and survival rate in endometrial carcinoma[ J ]. Cancer Lett, 2002,184 (1):105- 116.
  • 7Saitoh Y, Yaginuma Y, lshikawa M. Analysis of Bcl- 2 Bax and Survivin genes in uterine cancer[J]. Int J Onco, 1999,31 : 1080 - 1085.
  • 8Lehner R, Encmoto T, McGregar GA, et al. Correlation of Survivin mRNA detection with histological diagnosis in normal endometrium and endometrial carcinoma[J]. Acta Obstet Gynecol Scand, 2002,81 : 162 - 167.
  • 9管睿,马丽杰,崔英,余龙.Survivin在子宫内膜癌组织中的表达及其临床意义[J].实用癌症杂志,2006,21(1):39-41. 被引量:5
  • 10Hao X, Bishop AE, Wallace M, et al. Early expressin of cyciooxygenase- 2 during sporadic colorectal carcinogenesis[J]. J Pathol, 1999,187:295.

二级参考文献9

  • 1American Cancer Society Endometrial Cancer Detailed Guide 2004.1http://documents. cancer. org/140.00/140.00. pdf
  • 2Kinkel K, Kaji Y, Kyle K, et al. Radilolgic staging in patients with endometrial cancer: A mera-analysis. Radiology, 1999,212: 711
  • 3Folsom AR, Demissie Z, Harnack L. Glycemic index, glycemic load,and incidence of endometrial Cancer. Nutrition and Cancer, 2003,46(2): 119
  • 4曹泽毅主编.中华妇产科学(第1版)[M].北京:人民卫生出版社,1999:1854~1872.
  • 5Ambrosini G,Adida C,Altieri DC.A novel anti-apoptosis gene,survivin,expressed in cancer and lympHoma[J].Nat Med,1997,3(8):917.
  • 6Tamm I,Wang Y,Sausville E,et al.IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95),Bax,caspases,and anticancer drugs [J ].Cancer Res,1998,58(23):5315.
  • 7Tarkowski R,Wojcierowski J,Polak G,et al.Expression of the survivin gene in normal and hyperplastic endometrium [J ].Ginekol Pol,2000,71 (9):1226.
  • 8Konno R,Yamakawa H,Utsunomiya H,et al.Expression of survivin and bcl-2 in the normal human endometrium[J].Mol Hum Reprod,2000,6(6):529.
  • 9Lehner R,Enomoto T,McGregor JA,et al.Correlation of survivin mRNA detection with histologic diagnosis in normal endometrium and endometrial carcinoma [J ].Acta Obstet Gynecol Scand,2002,81(2):162.

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