摘要
目的:观察疏血通注射液对脑梗死患者P-、L-选择素表达及对炎症反应的影响,研究其干预脑缺血后炎症反应的环节及作用机制。方法:将诊断明确的急性脑梗死住院患者80例随机分为2组,治疗组40例,对照组40例。对照组给予西医常规治疗:抗血小板聚集、控制脑水肿、改善脑血循环、改善脑细胞代谢、防治并发症及支持疗法;治疗组在对照组的基础上加用0.9%生理盐水250mL+疏血通注射液6mL,每天1次,连续使用14天。对比2组治疗前后临床疗效及P-、L-选择素及炎症指标C反应蛋白(CRP)的变化。结果:治疗组愈显率72.5%,有效率92.5%,高于对照组(50%和75%,P<0.05)。治疗后2组患者临床神经功能缺损评分均有明显改善(P<0.05),治疗组改善更明显(P<0.05);治疗后2组血P-、L-选择素、CRP均有明显改善(P<0.05),治疗组在血P-、L-选择素、CRP的改善方面优于对照组(P<0.05)。结论:疏血通注射液治疗急性脑梗死患者有较好的疗效,其作用机制与干预急性脑梗死患者P-、L-选择素的表达,调节炎症反应有关。
Objective：To observe the impact of Shuxuetong on the expression of P- selectin, L- selectin, and C-reactive protein in the condition of acute cerebral infarction, and study the intervention mechanism thereof. Methods： Eighty patients were randomized to receive Shuxuetong （6ml, diluted with 250ml 0. 9% Sodium Chloride, once per day） plus routine treatments （anti-platelet aggregation, etc. ） for 14 consecutive days, controlled by those receiving the routine treatments only （ anti-platelet aggregation, etc. ）. The clinical effect, P-, L- selectin, and CRP were observed. Results： The significant effective rate （72.5%） and effective rate of （92.5%） of the treatment group were higher than those of the control group （50%, 75%, P 〈 0. 05 ）. After treatment, both groups improved in all abovementioned parameters （P 〈 0. 05 ）, with the treatment group being significantly better （ P 〈 0. 05 ）. Conclusion： By intervening the expression of P- selectin, L- selectin, and regulating inflammatory reaction, Shuxuetong Injection has satisfactory therapeutic effect on acute cerebral infarction.
出处
《世界中医药》
CAS
2010年第1期21-23,共3页
World Chinese Medicine
基金
广西卫生厅自筹经费科研课题(E2007189)
广西中医学院自然科学研究课题(P2006089)
关键词
急性脑梗死/中医药疗法
@疏血通注射液
Acute cerebral infarction/ Chinese medical therapy
@ Shuxuetong Injection
