摘要
目的将益生菌双歧杆菌与枸杞多糖提取物设计为口服结肠定位给药系统(OCDDS),制备0710合生元结肠靶向微生态调节剂,考查其体外释放行为及体内定位作用。方法以枸杞中多糖为指标,对制剂进行体外溶出实验,并利用X-射线跟踪技术验证0710合生元结肠靶向微生态调节剂在人体内的靶向性。结果该制剂在人工胃液2 h、人工小肠液4 h,几乎不释药,而在人工结肠液中6 h释药达到100%,符合中国药典2005年版对缓释制剂的规定,且体内实验在结肠中黏附性较好。结论0710合生元结肠靶向微生态调节剂在体外结肠液中释放良好,在体内结肠具有靶向性,达到制剂设计要求。
Objective To design the oral colonic drug delivery system （OCDDS） and prepare 0710 colonic targeting synbioties microecological modulator, combining bifidobacterium and medlar amylose, and in vitro release characteris- tics and colonic-targeting behavior in vivo was investigated. Method Dissolution testing was studied taking amylose as the index, and the X-Ray tracing technique was applied to inspect the colonic-targeting behavior of 0710 OCDDS in vivo. Result The amylose was not released in simulated gastric juice in 2h and in simulated small intestinal juice in 12 h, but reached up to 100% in simulated colon juice in 6 h, accord with the the sustained-release preparation requirements in Chinese Pharmacopoeia 2005 edition, and had a better adhesion in vivo. Conclusion The 0710 OCDDS has a good colon specific drug release and targeting effect in colon, meeting the design requirements of preparations.
出处
《中国微生态学杂志》
CAS
CSCD
2010年第1期29-31,35,共4页
Chinese Journal of Microecology
基金
"973"项目"微生态调节剂防治感染的基础研究"(2007CB513008)
关键词
微生态调节剂
口服结肠定位系统
体外释放
体内定位
Microecolog/cal modulator
Oral colonic drug delivery system
In vitro release
Localization
