摘要
目的研究肺部真菌感染的易患因素、临床特征、治疗结果和预后。方法应用回顾性的调查方法对106例肺部真菌感染患者进行分析。结果92.5%(98/106)的病例患有慢性阻塞性肺疾病(COPD)、系统性红斑狼疮(SLE)、白血病和慢性肾病等基础疾病,原发性肺部真菌感染少见。肺部真菌感染的临床表现无明显特异性,早期诊断仍比较困难,X线表现以支气管肺炎多见(占59.4%)。病原菌主要以酵母菌属为主(79.2%)。肺部真菌感染的预后较差,病死率较高,基础病为慢性肾病、COPD和血液系统疾病者死亡风险较大。结论肺部真菌感染是多种疾病继发感染的重要原因,其临床表现特异性少,病死率高,发病呈上升趋势,应引起临床高度重视。
Objective To find out the clinical features,therapeutic outcome, prognosis and the major predisposing factors for pulmonary fungal infection(PFI). Method 106 cases with PFI were retrospectively analyzed. Result Various predisposing, diseases were found in 92.5 % of total cases , among which, COPD, systemic lupus erythromatus ( SLE), leukemia and chronic renal disease were main predisposing diseases. Primary pulmonary fungal infection was rare. All the clinical manifestations of PFI were not specific, reontgenographic features showed mainly bronchitis type (59.4%). Monilia (Candida) ranked the first in pathogens (79.2%). The mortality of PFI was high. Chronic renal,COPD and hematologi- cal diseases might be the risk factors for mortality. Conclusion PFI is an important cause of the secondary infection in many diseases. The clinical features of PFI is non-specific and the morbidity was rising. CLinicians should pay more attention to it.
出处
《中国微生态学杂志》
CAS
CSCD
2010年第1期56-58,63,共4页
Chinese Journal of Microecology
关键词
肺
真菌感染
临床分析
Lung
Fungal infection
Clinical analysis