摘要
目的:探讨去卵巢大鼠脑电图的变化及中药复方柴胡加龙骨牡蛎汤对其影响。方法:以去卵巢大鼠为动物模型,采用大鼠皮层脑电图描记技术,从睡眠时相方面阐明柴胡加龙骨牡蛎汤改善更年期失眠症的药理作用。结果:去卵巢大鼠睡眠时相中的慢波睡眠深睡期(Slow wave sleep 2,SWS2)持续时间明显低于假手术组,给予柴胡加龙骨牡蛎汤7d后能明显延长自由活动去卵巢大鼠SWS2,对SWS1(Slow wave sleep1,慢波睡眠浅睡期)和REMS(rapid eyes movement sleep,快速眼球运动睡眠)没有明显的影响。结论:柴胡加龙骨牡蛎汤具有改善去卵巢大鼠睡眠的作用。
Objective： Research the change of EEG about ovaries removal rats and the effect by Chaihujialonggumuli Decoction. Methods： Use the ovaries removal rats as models and adopt rat EEG technology. Illuminate the pharmacologic action of improve menopause insomnia by Chaihujialonggumuli Decoction from sleeping phase. Result ： The duration of SWS2 （ slow wave sleep 2） in the sleeping phase of ovaries removal rats was dramatic lower than those sham operated. It can extend SWS2 obviously of free-running ovaries removal rats after 7 days by a Chaihujialonggumuli Decoction, however, no visible influence on SWS1 and REM. Conclusion Chaihujialonggumuli as the effect on improve the sleeping of ovaries removal rats.words：
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2010年第1期38-39,共2页
JOURNAL OF BASIC CHINESE MEDICINE
基金
黑龙江中医管理局资助项目(ZY06-W11)
关键词
脑电图
柴胡加龙骨牡蛎汤
去卵巢
EEG
Chaihujialonggumuli Decoction
ovaries removal
