摘要
目的探讨血必净注射液对大面积撕脱伤患者炎症因子的影响。方法70例患者按随机配对原则分为对照组和治疗组各35例。对照组患者入院后给予常规综合治疗；治疗组患者在对照组治疗基础上加用血必净注射液501111溶于生理盐水100ml静脉滴注，60min／次，2次／d，连用7d。检测两组治疗前及治疗后7d的肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、C-反应蛋白（CRP）、白细胞计数（WBC）及中性粒细胞百分比（NEU％），观察创面渗出情况的变化。结果治疗组治疗后7d各检测指标较治疗前明显改善，经处理有统计学意义（TNF-α：t=16．58，P〈0．01；IL-6：t=12．55，P〈0．01；CRP：t=29．64，P〈0．01；WBC：t=29．03，P〈0．01；NEU％：t=18．81．64，P〈0．01）。两组治疗7d后各项指标比较差异均具有统计学意义（TNF-α：t=-29．46，P〈0．01；IL-6：t=-16．93，P〈0．01；CRP：t=-20．36，P〈0．01；WBC：t=-10．11，P〈0．01：NEU％：t=-15．24，P〈0．01）。治疗组创面的渗出少于对照组。结论血必净注射液对大面积撕脱伤患者的炎症因子具有拮抗作用，并可减少创面渗出。
Objective To investigate the infection of Xuebijing injection on inflammatory factor of large sized avulsion patients. Methods 70 patients being selected with large sized avulsion were randomly recruited into a treatment group （35 patients） and a control group （35 patients）. The control group received traditional comprehensive treatment. On this basis, Xuebijing injection was injected to the treatment group on admission day, and Xuebijing injection 50 ml in 0.9%NaCl solution 100 ml was intravenously infused for 60 rain once, 2 times daily, up to 7 d. TNF-α, IL-6, CRP, WBC and NEU% of the two groups were respectively detected before treatment and 7 days after the treatment. Exudation of wound surface was also observed. Results After 7 days of treatment, there was significant difference in the treatment group compared with pretreatment （P〈0.01 ）. There was statistical difference between two groups after 7 days of treatment （P〈0.01）. Exudation of wound surface of the treatment group was less than the control group＇s. Conclusion Xuebijing injection has antagonistic effect on inflammatory factor of large sized avulsion patients and can lessen exudation of wound surface.
出处
《国际中医中药杂志》
2010年第1期24-25,共2页
International Journal of Traditional Chinese Medicine
关键词
血必净
撕脱伤
炎症因子
Xuebijing Injection
Avulsion Injury
Inflammatory Factor
