摘要
对健康日本大耳白兔注射不同剂量的地塞米松,通过制作肝脏组织切片,观察肝脏组织变化,探讨不同剂量地塞米松长时间运用于机体对肝脏组织的影响。25只健康日本大耳白兔随机分成5组,每天分别皮下注射不同剂量的地塞米松,于第21天后,处死试验兔,制作肝脏组织切片并进行观察。结果显示,基础剂量组肝细胞结构清晰,无变形与坏死;2倍剂量组肝脏组织出现不同程度的肝细胞空泡样变性,红细胞大量沉积;4倍及最大剂量组肝脏组织发生了严重病理变化。
With the development of animal clinical medicines, dexamethasone is more important in clinical application. The high dose dexamethasone used in long time would damage the liver. 25 healthy adult rabbits were randomly divided into 5 groups and administracted with different doses of dexamethasone. After 21 days, rabbits were killed and the livers of rabbits were collected,and pathological lesions of liver were observed under light microscope. The results showed that the cell structure of liver in basic group was clear, there was no denaturation and necrosis. In other groups,the cell structure disorder, the cell swelling,and some erythrocyts were found.
出处
《动物医学进展》
CSCD
北大核心
2010年第2期56-59,共4页
Progress In Veterinary Medicine
基金
云南农业大学动物科技学院科学研究基金(YNDKDYKY0701)
关键词
剂量
地塞米松
肝
组织形态
dose
dexamethasone
liver
histomorphology
