摘要
目的观察黄芪注射液配合化疗对晚期结直肠癌术后患者生活质量的影响。方法将60例晚期结直肠癌术后患者随机分为2组。2组均采用注射用奥沙利铂(L-OHP)+5-氟尿嘧啶(5-Fu)+注射用亚叶酸钙(CF)方案化疗,21d为1个周期,治疗3个周期。治疗组30例于化疗前3d开始,给予黄芪注射液配合化疗治疗,至化疗结束。对照组30例单纯应用化疗治疗。观察2组近期疗效、生活质量及毒性反应的发生情况。结果治疗组、对照组肿瘤缓解率分别为40.0%、33.3%,2组比较差异无统计学意义(P>0.05)。2组生活质量情况比较,食量不受化疗影响:治疗组24例(80.0%),对照组16例(53.3%),治疗组优于对照组(P<0.05)。睡眠改善:治疗组22例(73.3%),对照组13例(43.3%),治疗组优于对照组(P<0.05)。体质量及卡氏评分:治疗组治疗后比治疗前增加(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05);2组治疗后卡氏评分比较差异有统计学意义(P<0.05)。毒性反应:2组外周静脉炎、周围神经毒性发生率比较差异有统计学意义(P<0.05)。结论黄芪注射液配合化疗对改善晚期结直肠癌术后患者生活质量、减轻化疗毒性反应有一定效果。
Objective To express the effect of Huangqi injection combined with chemotherapy on quality of life of postoperation patients with advanced stage eolorectal carcinoma. Methods 60 postoperation patients with advanced stage eolorectal carcinoma were randomly divided into two groups. Patients in two groups were initially treated by chemotherapy of （L-OHP） ＋ （5 -Fu） ＋ （CF）. The course was 21 days in two groups. Three courses were carried on. Patients in treatment group （ n = 30） were treated by Huangqi injection three days before chemotherapy. Patients in control group （ n = 30） were treated only by chemotherapy. The recent effect, life quality and toxic reaction were observed. Results There was no significant difference between two groups on remission rate of tumor （ P 〉 0.05 ）. The numbers no change of food - intake in treatment group （ 80.0% ） was higher than that in control group （53.3%, P 〈0.05）. The improvement of sleep and KPS in treatment group （73.3%） was superior to that in control group （43.3%, P 〈 0.05, P 〈 0.05 ）. The improvement of peripheral phlebitis and neurotoxicity in treatment group （ 16.7 % ,33.3 % ） were superior to those in control group （43.3 %, 70.0%, P 〈 0.05 ）. Conclusion Radix Astragali combined with chemotherapy has definite effect on quality of life of postoperation patients with advanced stage colorectal carcinoma, and can relief toxicity of chemotherapy.
出处
《河北中医》
2009年第11期1696-1698,共3页
Hebei Journal of Traditional Chinese Medicine
关键词
结直肠肿瘤
中西医结合疗法
黄芪
治疗运用
生活质量
Colorectal carcinoma
Therapy of combination of Traditional Chinese Medicine with Western medicine
Radix Astragali
Application of treatment
Quality of life
