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CD40-CD40L与OX40在急性髓性白血病中的表达意义 被引量：1

The Expression of CD40/CD40L and OX40 in Acute Myeloid Leukaemia
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摘要 目的:检测在急性髓性白血病细胞中CD40、CD40L、OX40的表达并探讨其临床意义。方法:应用流式细胞仪检测46例未经治疗的初诊急性髓性白血病患者骨髓单个核细胞表面CD40、CD40L、OX40的表达,分为四组:仅表达CD40的患者组(①组)、表达CD40+CD40L+OX40-的患者组(②组)、三种抗原全部表达组(③组)和全部不表达组(④组)。利用SPSS统计软件分析。结果:在有高白细胞表现的患者中,②组的发病率(100%)最高;在有血小板减少表现的患者中,①组的发病率(100%)最高;在有脾大表现的患者中,④组的发病率(6.7%)最低。结论:CD40的单独表达可能使白血病患者血小板的降低更加严重,而当合并CD40L表达时,会减少血小板低下的发生率。CD40的表达能增加患者伴有脾大表现的可能性。 Objective：To detect the expression of CD40/CD40L and OX40 in acute myeloid leukaemia （AML） and explore its clinical significance. Methods： using flow eytometry （FCM） to detect the expression of CD40, CD40L, OX40 on mononuclear cells which were from 46 untreated patients with newly diagnosed AML. Then separation to four groups： the only expression CD40 antigen group （1）, the expression CD40＋ CD40L＋OX40- group （（2））, the expression three antigen group （3）, the expression none of antigen group （4）. Results： In high leukocyte symptom patients, group （2） incidence was highest; in thrombocytopenic patients, group （1）incidence（ 100% ） was highest; In splenauxe symptom patients group （4） was lowest. Conclusion：The single expression CD40 can lead to heavier low thrombocytic. Together with expression of CD40L can lead to lower incidence of low platelet. The expression of CD40 may increase splenauxe symptom incidence.
作者 师帅帅 乔振华
机构地区 长治医学院附属和济医院肾内科 山西医科大学
出处 《长治医学院学报》 2009年第6期404-407,共4页 Journal of Changzhi Medical College
关键词 白血病 CD40 CD40L OX40 Leukaemia CD40 CD40L OX40
分类号 R392 [医药卫生—免疫学]
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参考文献10

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二级参考文献27

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长治医学院学报
2009年 第6期

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