摘要
为探讨缺血型脑血管疾病的早期诊断、其损伤区域的初步确定以及脑功能的检查方法，研究了缺血性脑损伤特征信息早期无创提取和分析的实用技术。通过建立ＳＤ大鼠局灶性缺血脑损伤实验模型，记录缺血前到缺血３０ｍｉｎ缺血区域与正常区域的脑电图（ＥＥＧ）。应用三阶递归（ＴＯＲ）方法估计双谱，分析局灶性缺血脑损伤ＥＥＧ的信号特征。结果表明，损伤发生时，损伤区域的ＥＥＧ双谱的分布发生变化。在损伤的不同阶段，损伤区域与非损伤区域双谱最大值以及加权双谱中心（ＷＣＯＢ）有明显不同的变化。提示，ＥＥＧ信号的双谱对局灶性缺血脑损伤十分敏感，可以对损伤程度进行诊断，区分损伤区域与非损伤区域。
Early noninvasive detection of cerebral ischemia is important for fighter pilots as well as in clinical diagnosis. In this paper, a model of focal cerebral ischemia was presented. Bispectrum of EEG signals recorded from ischemic region and normal region after 30 min ischemia was analyzed using the third-order recursion method, which possesses higher frequency resolving ability. It can resolve two closely spaced peaks in the bispectrum and detect the presence or absence of quadratic phase coupling at frequency pairs that are very close to each other. It was found that some characteristics of such bispectrum are very sensitive to focal cerebral ischemia. The maximum bispectrum magnitude of EEG and the weighted center of bispectrum (WCOB) changed sensitively to the different ischemic regions and ischemic stages. The ischemic and normal regions as well as the degree of ischemia can be clearly distinguished by analyzing their bispectrum of EEG. It demonstrates that this method can be used as a quantitative method for the detection of focal cerebral ischemia in the early phase.
出处
《航天医学与医学工程》
CAS
CSCD
1998年第2期97-101,共5页
Space Medicine & Medical Engineering
基金
西安交通大学博士学位论文基金
