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急性创伤性凝血病的诊疗进展 被引量:32

The Diagnosis and Treatment of Acute Traumatic Coagulopathy
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摘要 急性创伤性凝血病是创伤早期出现的急性凝血功能紊乱。它是相互影响的多重机制共同作用的结果,包括:组织损伤是凝血和纤溶的启动因素;休克是其最初的驱动因素,凝血启动的同时激活了抗凝和纤溶途径;血液稀释、低体温、酸中毒和炎性反应等加剧了已经存在的凝血病。早期诊断凝血病依赖于临床细致的观察和实验室检查。损伤控制复苏和纠正严重创伤伴发的"致命性三联征"是目前处理急性创伤性凝血病的重要措施,基因重组活化FⅦ是一个很有前景的促进凝血酶生成的强效药物。 Acute traumatic coagulopathy is a kind of acute coagulation dysfunction in the early stage of trauma. Acute traumatic coagulopathy is the result of multiple independent but interacting mechanisms, including the following factors : tissue injury, coagulation, fibrinolysis, shock, antieoagulation, hemodilution, hypothermia,acidemia and inflammation, Early identification of coagulopathy is dependent on careful clinical observation and laboratory examination. Tissue repair and the management of "lethal Triad" are the main treatment strategies of acute traumatic coagulopathy. The recombinant activated FⅦ (rFⅦa) is a potent medication due to its ability to increase thrombin generation.
出处 《医学综述》 2010年第3期407-410,共4页 Medical Recapitulate
关键词 创伤性凝血病 病理生理 诊断 治疗 Traumatic coagulopathy Pathophysiology Diagnosis Therapy
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