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5-氨基-5,6,7,8-四氢-2(1H)-喹啉酮的简便合成 被引量:4

Facile Synthesis of 5-Amine-5,6,7,8-tetrahydro-2(1H) quinolinone
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摘要 改进了合成5-氨基-5,6,7,8-四氢-2(1H)喹啉酮(5)的方法。以环己二酮为原料,通过亚胺化,Michael反应-环化反应,成肟反应和碱性条件下镍铝合金催化还原共四步反应合成了5,总收率19.6%,其结构经1HNMR,IR和MS确证。 The synthesis method for 5-amine-5,6,7,8-tetrahydro-2 (1H) quinolinone ( 5 ) was improved. 5 in total yield of 19.6% was simply prepared from 1,3-cyclohexadione (1) by a four-step reaction of imination, Michael reaction-intermolecular cyclization and oximation, followed by reduction in the presense of Ni-Al alloy catalyst under alkali condition. The structure was characterized by ^1H NMR, IR and MS.
出处 《合成化学》 CAS CSCD 北大核心 2010年第1期94-96,共3页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(20672147) 国家"十一五"科技支撑计划资助项目(2006BAEA01-4-01) 中南大学青年教师基金资助项目
关键词 喹啉酮 镍铝合金 还原 合成 quinolinone Ni-Al alloy reduction synthesis
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