摘要
目的:评价D-木糖吸收率在肝硬化门静脉高压进程中的变化规律,欲探索一种非损伤性且简便实用的推测门静脉压力的方法.方法:SD大鼠80只,♂,体质量180-220g,随机分为:正常组5只,正常饮水,正常饮食.肝硬化门脉高压诱导组75只,共成模55只,前5wk使用0.03%硫代乙酰胺,后5wk使用0.04%硫代乙酰胺作为其饮水,停药后6wk仍继续观察肝组织及门静脉压力变化.正常组及第2、4、6、8、10、11、12、13、14、15、16周共12组,对每组大鼠检测尿D-木糖含量及门静脉压力,并计算D-木糖吸收率与相应的门静脉压力的相关性.结果:在肝硬化进程中自第8周纤维间隔明显增生,肝小叶结构紊乱,部分可见假小叶,同时门静脉压力及D-木糖吸收率也是自第8周开始同步出现显著性差异.D-木糖吸收率与门静脉压力呈负相关,具有统计学意义(r=-0.697,P<0.01),同时得出两者的直线关系方程:y=-0.01x+0.2791.结论:D-木糖吸收率可以反映肝硬化门静脉压力的变化趋势,对于临床上判断门静脉压力的大小、评价治疗效果具有重要意义.
AIM: To evaluate the dynamic changes in D-xylose absorption rate during the progression of portal hypertension to find a noninvasive and practical method to evaluate portal pressure. METHODS: Eighty male Sprague-Dawley rats, weighing 180-220 g, were randomly divided into two groups: normal control group (n = 5) and model group (n = 75). Fifty-five model rats were randomly divided into 11 subgroups (n = 5). The normal control group was given normal drinking water, while the model group was given 0.03% thioacetamide (TAA) for 5 weeks and 0.04% TAA for another 5 weeks. The pathological changes in the liver and portal pressure were monitored until 6 weeks after withdrawal of TAA. The D-xylose content of the urine and portal pressure were determined at weeks 2, 4, 6, 8, 10, 11, 12, 13, 14, 15, and 16, respectively. The correlation between D-xylose absorption rate and portal pressure was analyzed. RESULTS: At week 8, apparent fibrous septum hyperplasia, disorganized hepatic lobule architecture, and even pseudolobules were observed. Meanwhile, portal vein pressure and D-xylose absorption rate began to show significant changes. The D-xylose absorption rate is inversely correlated with portal vein pressure (P〈0.01). The correlation coefficient is-0.697, and the linear equation is: y =-0.01x + 0.2791. CONCLUSION: D-xylose absorption rate can reflect the changes in hepatic portal pressure and can be used to predict portal hypertension pressure and evaluate therapeutic effects in clinical practice.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第1期9-13,共5页
World Chinese Journal of Digestology
关键词
门静脉高压
D-木糖吸收率
尿D-木糖含量
肝硬化
Portal hypertension D-xylose absorption rate D-xylose content of the urine Cirrhosis