摘要
目的：研究胰岛素治疗中三种不同血糖控制目标对危重颅脑疾病病人蛋白质代谢的影响。方法：将122例危重颅脑疾病病人随机分为三组,分别给予胰岛素控制血糖于不同的目标,即A组41例,血糖控制在4.46.1 mmol/L）;B组42例,血糖控制在6.18.3 mmol/L,C组39例,血糖控制在1011.1 mmol/L。对三组病人的蛋白质代谢情况和低血糖发生率进行比较。结果：A组与B组氮平衡、PA和TF指标优于C组,差异有显著性意义（P〈0.05）;但低血糖发生率A组高于B组和C组（P〈0.05）。结论：病人血糖控制在≤8.3 mmol/L,有利于减轻严重颅脑疾病病人的高分解代谢,促进蛋白合成,改善营养状况。
Objective： To investigate the effect of three different goals of blood glucose control by insulin therapy on protein metabolism in the patients with critically cerebral disease.Methods： We performed a prospective,randomized,controlled study.A total of 122 patients with critically cerebral disease were randomly divided into three groups according to the target glucose-control levels：Group A： 4.4-6.1 mmol/L（n=41）,Group B： 6.1-8.3 mmol/L（n=42）,and Group C： 10-11.1 mmol/L（n=39）.The state of protein metabolism and ratio of hypoglycemia of three groups were compared.Results： The indicators of nitrogen balance,prealbumin and transferrin in group A and group B were significantly better than that in group C（P〈0.05）,but the ratio of hypoglycemia in group A was significantly higher than those in group B and group C（P〈0.05）.Conclusion： Maintaining the blood glucose level ≤8.3 mmol/L might improve the nutrition status in the patients with critically cerebral disease by decreasing catabolism and promoting synthesis of protein.
出处
《肠外与肠内营养》
CAS
北大核心
2010年第1期8-10,共3页
Parenteral & Enteral Nutrition
基金
温州市卫生局基金资助项目(2008055)
关键词
颅脑疾病
胰岛素
血糖
蛋白质代谢
Craniocerebral disease
Insulin
Blood glucose
Protein metabolism
