摘要
目的探讨服用炔雌醇环丙孕酮片(商品名:达英-35)对非肥胖型多囊卵巢综合征(PCOS)患者内分泌代谢的影响。方法53例非肥胖型PCOS患者接受达英-35治疗,持续6个周期。于治疗前及治疗后第3个和第6个周期末,记录体质量指数、腰臀比、多毛评分和痤疮评分;于早卵泡期及治疗后第3个月和第6个月末,测定血清总睾酮、黄体生成素、卵泡刺激素、空腹血糖、空腹胰岛素,计算黄体生成素/卵泡刺激素比值和胰岛素抵抗指数(HOMA-IR)。结果治疗前后患者体质量指数和腰臀比无明显变化;与治疗前比较,治疗后两时间点的多毛评分、痤疮评分、血清总睾酮和黄体生成素水平及黄体生成素/卵泡刺激素比值均显著降低(P<0.05)。伴有胰岛素抵抗患者治疗后6个周期末的体质量指数和HOMA-IR明显高于治疗前(P<0.05)。结论短期服用达英-35可明显改善非肥胖型PCOS患者的高雄激素血症。对于同时伴有胰岛素抵抗的非肥胖型PCOS患者,达英-35存在加重其胰岛素抵抗程度的可能。
Objective To investigate the effects of ethinylestradiol and cyproterone acetate tablets （Diane-35） on endocrine metabolism in non-obese women with polycystic ovary syndrome（PCOS）. Methods Fifty-three non-obese patients with PGOS were assigned to the 6-month treatment with Diane-35. Body mass index （BMI）, waist to hip ratio （WHR）, F-G score and ache score were recorded before treatment and at the end of the third and sixth cycle after treatment. Serum total testosterone, follicle stimulating hormone （FSH）, luteinizing hormone（ LH）, LH/FSH, fast plasma glucose, fast insulin and insulin resistance index （HOMA-IR） were obtained at early follicular phase and at the end of the third and sixth month. Results There was no significant change in BMI and WHR after treatment. Compared with those before treatment, F-G score, acne score, serum total testosterone, LH and LH/FSH were significantly decreased at two time points after treatment （P 〈0.05）. BMI and HOMA-IR in patients with insulin resistance were significantly higher at the end of the sixth cycle after treatment than those before treatment （ P 〈0.05）. Conclusion Diane-35 can improve hyperandrogenism in nonobese patients with PCOS. However, Diane-35 may aggravate insulin resistance in those with insulin resistance.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第2期168-170,185,共4页
Journal of Shanghai Jiao tong University:Medical Science
关键词
多囊卵巢综合征
炔雌醇环丙孕酮片
胰岛素敏感性
高雄激素血症
polycystic ovary syndrome
ethinylestradiol and cyproterone acetate tablet
insulin sensitivity
hyperandrogenism
