摘要
目的探讨CD44v6和Survivin蛋白在原发性胆囊癌组织中的表达与癌组织类型、病理分级和转移状况的关系,以及CD44v6与Survivin表达之间的相关性。方法应用免疫组化方法检测52例胆囊腺癌、20例胆囊腺瘤和20例慢性胆囊炎组织中CD44v6和Survivin表达水平。结果胆囊癌组织中CD44v6和Survivin阳性表达率分别为80.8%(42/52)和67.3%(35/52),均明显高于胆囊腺瘤(分别为45.0%和30.0%,P<0.05),并随着胆囊癌的分化程度减低、病理分级增高和转移而明显增高(P<0.05)。同时,CD44v6表达与Survivin表达呈明显正相关(χ2=5.19,P<0.05)。结论CD44v6和Survivin均是胆囊癌高度恶化和预后不良的重要指标。胆囊癌CD44v6表达与Survivin表达可能具有协同作用。
Objective To study the relationship of CD44v6 and Survivin protein expression with histological type, pathological grading and metastasis. Methods Immunohistochemical method was used to investigate the expression of CD44v6 and Surviving protein in 52 cases of gallbladder carcinoma, 20 of gallbladder adenoma and 20 of chromic cholecystis. Results The positive rate of CD44v6 and Survivin was 80.8%（42/52） and 67.3%（35/52）, which was positively correlated with the histological type, pathological grading and metastasis of gallbladder carcinoma （P〈0.05） and higher than that in gallbladder adenoma （CD44v6 45.0% and Survivin 30.0%, respectively）. Expression of CD44v6 was positively correlated with the expression of Survivin （X2=5.19, P〈0.05）. Conclusion CD44v6 and survivin may be important biologic markers to evaluate the malignancy and prognosis of gallbladder carcinoma. There may be some extent coordinated function between them.
出处
《肝胆胰外科杂志》
CAS
2010年第1期42-44,共3页
Journal of Hepatopancreatobiliary Surgery
