摘要
目的:研究α-亚麻酸和γ-亚麻酸对高脂血症人群血脂水平的影响。方法:选取血清总胆固醇≥5.2mmol/L及甘油三酯≥1.65mmol/L的自愿受试者106人,随机分为对照组和试验组,试验采用双盲试验。对照组每天服用含α-亚麻酸400mg,γ-亚麻酸120mg的软胶囊3粒,对照组服用外形相同的安慰剂3粒。实验前后分别观察人血清TG、TC、HDL-C变化及一般状况。试验周期为45天。结果:与对照组比较,试验组血清TC、TG水平显著降低,血清HDL-C水平显著上升;试验组自身比较,试验后血清TC和TG水平显著降低,血清HDL-C水平显著升高;对照组自身比较,试验后血清TC、TG、HDL-C水平差异均无显著变化;试验组TC、TG、HDL-C有效率及总有效率明显高于对照组。在试验期间受试者的精神、睡眠、饮食、在小便、血压、各项临床指标等均未见异常,未见其它不良反应。结论:α-亚麻酸和γ-亚麻酸具有辅助降血脂功能,且对机体健康无不良影响。
Objective：To investigate the effects ofα-linolenic acid andγ-linolenic acid on the blood-lipid levels of the people with hyperlipidemia.Methods：106 subjects who the serum total cholesterol（TC）level≥5.2mmol/L and triglyceride（TG）level≥ 1.65mmol/L were randomly divided into 2 groups,the experimental group was given 3 soft capsules containingα-linolenic acid and γ-linolenic acid at levels of 400mg/d and 120mg/d,respectively.Control group was provided 3 similar soft capsules within placebo.To observe the changes of TC,TG,HDL-C in the plasma and general condition before and after the experiment.The total process need 45 days.Result：As compared with the control group,the serum levels of TG,TC,decreased obviously,and HDL-C increase significantly in the experiment group.As compared with itself,in the experiment group the TG and TC levels in the blood decreased obviously,and HDL-C levels increased significantly at the end of the study.On the contrary,there were no significant difference on the levels of TC TG HDL-C in the control group.The effective power and total effective rate of TC TG and HDL-C in experiment group were more significant than in the control group.There was no abnormal on the mind,sleep,diet,and clinical indicators（e.g.urination,blood pressure） of the volunteers during the total process,moreover,there was no adverse reaction.Conclusion：α-linolenic acid andγ-linolenic acid were able to auxiliary decrease the levels of blood lipids and no adverse effect on the body＇s health.
出处
《现代生物医学进展》
CAS
2009年第23期4492-4495,共4页
Progress in Modern Biomedicine
