摘要
目的探讨高通量血液透析(HFHD)对维持性血液透析患者微炎症状态影响及对中大分子毒物的清除。方法选择40例血透患者,随机分为常规血液透析(CHD)组与HFHD组,每组各20例。以3个月为观察期,测定和比较2组单次透析前与透析后即刻差值,单次与3个月后透析前患者的超敏C反应蛋白(hs-CRP)、肌酐(Scr)、血红蛋白(Hb)、血磷(P3+)、β2-微球蛋白(β2-MG)水平。记录和比较单次透析前及3个月后二维超声心动图中心脏左房前后径(LAD)、室间隔厚度(IVST)的数值。结果①单次透析前后hs-CRP、Scr、Hb水平差值2组相比差异无统计学意义(P>0.05),P3+有统计学意义(P<0.05)。②β2-MG水平无论是在单次透析前后还是和3个月后2组相比均有统计学意义(P<0.01)。③3个月后HFHD组较CHD组hs-CRP、P3+水平与单次透析前相比有统计学意义(P<0.05);2组Scr、Hb、LAD、IVST数值水平与单次透析前相比无统计学意义(P>0.05)。结论HFHD与CHD对Scr等小分子物质清除无显著差异,HFHD可以较好地清除β2-MG等中大分子物质,进而改善患者微炎症状态。
Objective To explore the high-flux hemodialysis on the maintenance hemodialysis patients with micro-inflammatory state and effects on the removal of toxic molecules.Methods Selected 40 cases of hemodialysis patients were randomly divided into HFHD group and CHD group with 20 in each group.Three months were taken as an observation period.Determination and comparison of different levels of hs-CRP,Scr,Hb,P3＋,β2-MG were performed in two groups for the Pre-dialysis,immediately after hemodialysis,three months later.Record and comparison LAD,IVST values in the two-dimensional echocardiography of two groups on the beginning and after three months.Results ①The levels of hs-CRP,Scr,Hb before and after the first time dialysis all have no statistically significant between the two groups（P〉0.05）,P3＋ had statistically significant（P〈0.05）.②β2-MG levels either before and after the first dialysis or three months after were all have statistically significant in the two groups（P〈0.01）.③After three months,compared with the first time pre-dialysis the two groups levels of hs-CRP,P3＋ all had statistical significance（P〈0.05）;Scr,Hb,LAD,and IVST were no significant differences（P〉0.05）.Conclusion There was no significant difference ability of removed of small molecules between HFHD and CHD.HFHD can be well β2-MG clearance of macromolecules such as material,and then improving the micro-inflammatory state of patients.
出处
《江西医学院学报》
CAS
2009年第11期41-44,共4页
Acta Academiae Medicinae Jiangxi
基金
江西省卫生厅科技计划(051031)
关键词
高通量透析
常规血液透析
超敏C反应蛋白
血肌酐
大分子物质
血Β2-微球蛋白
high-flux dialysis
conventional hemodialysis
high-sensitivity C-reactive protein
serum creatinine
macromolecules
serum β2-microglobulin
