摘要
目的探讨急性脑梗死(ACI)并高血压患者血清脂蛋白(a)〔LP(a)〕水平变化及临床意义。方法选择ACI并高血压患者54例,ACI未合并高血压(单纯ACI)患者42例。均行经颅彩色多普勒(TCD)、头颅MRI及MRA检查。选择30例健康体检者为对照组。检测所有患者血清LP(a)水平,比较不同脑动脉供应系统和不同血管狭窄程度、不同梗死面积患者血清LP(a)水平变化。结果(1)ACI组LP(a)水平高于对照组,其中ACI合并高血压组高于单纯ACI组(均P<0.01)。(2)不同梗死面积脑梗死患者组间LP(a)水平呈现大梗死灶>小梗死灶>腔隙性梗死(均P<0.05)。(3)动脉狭窄以颈内动脉系统(70.6%)发生率最高,其LP(a)水平与椎基底动脉系统相比差异无统计学意义(P>0.05)。(4)多发脑动脉狭窄患者LP(a)水平高于单只动脉狭窄患者(P<0.05)。结论LP(a)与高血压具有协同作用,与急性脑梗死的发生密切相关。LP(a)作为急性脑梗死的危险因素,可预测患者的梗死面积和颅内血管梗阻的严重情况。
Objective To study the changes of lipoprotein(a)(LP(a)) in patients with acute phase cerebral infarction and hypertension.Methods Fifty-four patients with cerebral infarction and hypertension were selected.forty-two patients with only cerebral infarction were compared.They were all given TCD,MRI and MRA examination.Thirty healthy persons were selected as control group.For all patients,the concentrations of plasma LP(a) were measured.Results ①The plasma LP(a) increased significantly(P<0.01) in ischemic stroke group compared with control group,and stroke with hypertension more obvious than that without it.②The area of ischemic more large,PL(a) concentrations increased more significantly(P<0.05).③There was no conspicuous change(P>0.05) in PL(a) concentration between internal carotid artery system and basilar artery system.④The plasma LP(a) was more in dual stenosis than that in single stenosis(P<0.05).Conclusion LP(a) and hypertension have joint action to cerebral infarction.The changes of LP(a) concentrations in patients with ischemic stroke are related with the development of stroke.
出处
《中国实用神经疾病杂志》
2010年第3期12-15,共4页
Chinese Journal of Practical Nervous Diseases
关键词
脑梗死
脂蛋白(a)
高血压
危险因素
Cerebral infarction
Lipoprotein(a)
Hypertension
Risk factor
