摘要
目的探讨血清癌抗原125(CA-125)、癌胚抗原(CEA)和C-反应蛋白(CRP)联合检测对肺癌的诊断价值。方法收集确诊肺癌、COPD和正常组各40人,采用免疫放射法检测三组人群血清CA-125和CEA,散射比浊免疫法检测C-反应蛋白。结果肺癌患者血清CA-125和CEA表达水平均高于COPD和正常组(p<0.05);COPD组CRP表达水平高于肺癌和正常组(p<0.05)。联合检测CA-125、CEA和CRP对肺癌诊断的敏感性、特异性和准确性均显著优于各指标单独检测(p<0.05)。结论联合检测血清CA-125、CEA和CRP对肺癌的具有较好的诊断价值。
Objective To investigate the diagnostic value of serum CA - 125, CEA and CRP combined examination on lung carcinoma. Methods We enrolled 40 patients in each group who＇ s diagnosed as lung carcinoma, COPD or the normal people as control group. We used immtmoradioassay to evaluate serum CA - 125 and CEA expression, and nephelometry immunoradioassay to evaluate CRP. Results Serum CA - 125 and CEA level in lung carcinoma group are higher than in COPD and control groups（p 〈0. 05）. CRP in COPD group is higher than in lung carcinoma and control groups（p 〈 0. 05 ）. The sensitivity, specificity and accuracy of lung carcinoma diagnosis are higher in CA - 125, CEA and CRP combination than the isolated analysis （p 〈 0. 05 ）. Conclusion Diagnosis of lung carcinoma by combination of CA - 125, CEA and CRP analysis has a good clinical merit.
出处
《现代医院》
2010年第2期76-77,共2页
Modern Hospitals
关键词
肺癌
癌抗原125
癌胚抗原
C-反应蛋白
Lung carcinoma, Carcinoma antigen- 125, Carcinoma embyronic antigen, C- reaction protein
