摘要
胸腺素β4是真核生物细胞中的一种主要的肌动蛋白螯合分子,广泛分布于哺乳动物和其它脊椎动物的多种组织和有核细胞中。尽管其分子水平的作用机制尚不明确,但胸腺素β4却与人类的许多生理及病理过程密切相关。随着研究的进一步深入,胸腺素β4在临床上的潜在应用价值将被开发,这对于一些疾病的诊断、治疗及预防均具有重要意义。近年来对胸腺素β4的研究包括其在创伤愈合、肿瘤转移、血管再生等方面的生物学作用,同时,随着对胸腺素β4需求的增加,对利用基因工程的方法进行胸腺素β4生产的研究也在不断进行中。文中拟对近年来胸腺素β4在生物学功能和生产方法上所取得的进展进行综述。
Thymosin β4, which is widely distributed in many tissues and nucleated cells of mammals and other vertebrates, is a major actin chelating molecule in eukaryotic cells. Thymosin β4 has a close relationship with many physiological and pathological processes of human beings; however, its molecular mechanism is not yet clear. As the research work went further, the potential applications of thymosin β4 in clinical will be developed, it will bring significant effects to diagnosis, treatment and prognosis of some diseases. In recent years, the study of thymosin β4 focus on several physiological processes, including wound healing, neoplasm metastasis, angiogenesis, and so on, Along with the increasing demand of thymosin β4, production method were being developed. The recent progress on biological function and production of thymosin β4 was reviewed in this paper.
出处
《安徽农学通报》
2010年第4期38-44,51,共8页
Anhui Agricultural Science Bulletin