摘要
为了探讨吉西他滨+顺铂方案治疗中晚期食管癌的疗效及预后,对56例中晚期食管癌患者行吉西他滨+顺铂方案化疗,观察治疗前后影像学变化,全身、饮食状况,给予手术治疗或放疗。化疗后手术组18例,2例行颈部吻合,6例行食管胃弓上吻合,9例行食管胃弓下吻合术,1例行开胸探查术。开胸探查1例,患者术后未行综合治疗,生存期半年;颈部吻合1例,术后未行规范化治疗,生存期14个月;未行手术治疗组38例,中位生存时间13个月。初步研究结果提示,化疗后部分患者病变明显缩小,和周围脏器、组织、大血管边界变清晰,从而获得手术机会;未能手术治疗组患者全身、饮食状况改善。患者耐受性好,该化疗方案值得临床广泛推广应用。
The objective of this study was to summarize gemcitabine in combination with cisplatin therapty for advanced esophageal cancer about the efficacy and the prognosis. Fifty-six patients with advanced esophageal cancer. All the patients were treated with gemcitabine in combination with cisplatin. The image change, the status from head to foot and bite and sup were observed to decide the operation or the radiotherapy. After the chemotherapy 18 case were operated on, in which 2 cases of neck anastomose, 6 cases of oesophagus stomach anastomose up the bow, 9 cases of oesophagus-stomach anastomose under the bow. One cases of opening exploration died after 6 months without synthesis therapy; 1 case of the neck anastomosed died after 14 months without the sequence chemotherapy. Thirtyeight patients who could not be operated on were treated gemcitabine in combination with cisplatin therapty, and their average survival time was 13 months. In conclusion, gemcitabine plus cisplatin therapy was well tolerated and has a significant activity in patients with advanced esophageal cancer.
出处
《中华肿瘤防治杂志》
CAS
2009年第23期1887-1888,共2页
Chinese Journal of Cancer Prevention and Treatment
关键词
食管肿瘤/药物疗法
顺铂/药物疗法
药物疗法
联合
esophageal neoplasms
drug therapy
cisplatin/drug therapy
drug therapy, combination
