摘要
以玻碳电极为工作电极，在微波作用下采用循环伏安法研究了阿苯达唑的电化学特性，结果表明微波可以增大阿苯达唑的氧化峰电流，据此建立了一种新型检测阿苯达唑的电化学方法。在优化实验条件下，无微波作用时，响应电流与阿苯达唑的浓度在4．0×10-5～1．0×10-3mol／L范围内呈线性关系，线性方程为Ip（μA）=8．3036c（mmol／L）＋0．7271（r=0．9993，n=7），检出限为1．78×10-5mol／L；在80w微波作用下，阿苯达唑的峰电流增大近1倍，响应电流与阿苯达唑的浓度在2．0×10-5 -1．0×10-3mol／L范围内呈线性关系，线性方程为Ip（μA）=15．41c（mmol／L）＋1．4359（r=0．9989，n=8），检出限为1．01×10-5mol／L。研究表明，微波一循环伏安法测定阿苯达唑具有较高的选择性和灵敏度，且样品处理简单快速，用于阿苯达唑片的测定，结果满意。
A new electrochemical method for the determination of albendazole was described in the presence of microwave activation. The eleetrochemical characteristics of albendazole were studied by cyclic vohammetry（CV） at GC electrode in an environment of microwave radiation. A considerable current enhancement was observed for albendazole in pH 1.0 H2 SO4. The experimental conditions were optimized. Under the optimal conditions, albendazole was determined in the absence and presence of microwave activation. The result indicated that, in the absence of microwave activation, a good linear relationship between peak current and albendazole concentration in the range of 4. 0 × 10 -5 - 1.0 × 10 -3 mol/L with a detection limit of 1.78 × 10 -5 mol/L（S/N = 3 ） and a linear regres sion equation of 10（μA） =8. 303 6c（mmol/L） ＋0. 727 1 （r =0. 999 3, n =7）. In the presence of 80 W microwave activation, the calibration was linear for albendazole concentration in the range of 2. 0 × 10-5 - 1.0 × 10-3 mol/L with a detection limit of 1.01 × 10-5 mol/L（S/N = 3） and a linear regression equation of It, （μA） = 15.41c （mmol/L） ＋ 1. 435 9 （ r = 0. 998 9, n = 8 ）. The current of albendazole was about two times higher than that in the absence of microwave activation. The proposed method in the presence of microwave activation showed high selectivity, sensitivity, simple sample preparation, and was used for the determination of albendazole tablet with satisfactory results.
出处
《分析测试学报》
CAS
CSCD
北大核心
2010年第2期176-179,共4页
Journal of Instrumental Analysis
基金
广西自然科学基金资助项目(0832062)
国家自然科学基金资助项目(20665001)
关键词
微波
阿苯达唑
循环伏安法
microwave
albendazole
cyclic voltammetry
