摘要
目的探讨高强聚焦超声(HIFU)热疗联合局部放疗对不能手术切除的胰腺癌患者的疗效、安全性及对肿瘤标志物的影响。方法35例胰腺癌患者采用常规分割照射(每次1.8～2.0Gy,每周5次),放射治疗剂量为70～72Gy,平均每例患者接受3次HIFU治疗,对其进行疗效评价,观察患者的临床受益反应(CBR),并用化学免疫分析法检测消化道癌相关抗原(CA19-9)和癌胚抗原(CEA)浓度。结果35例胰腺癌患者中共20例临床受益,CBR率达57.14%。治疗前后CA19-9、CEA浓度比较,差异有统计学意义。在治疗过程中无明显不良反应。结论HIFU热疗联合局部放疗能控制肿瘤进展,改善生活质量,对肿瘤标志CA19-9、CEA有明显下调作用,无明显不良反应。
Objective To investigate the therapeutic effect,safety and the effect of two tumormarkers of high intensity focused ultrasound（HIFU）in treating pancreatic carcinoma.Methods The 35 patients suffering from pancreatic carcinoma were treated with 6 times FEP by the conventional fractionation（1.8-2.0Gy/t,5times/week）at dose of 70-72Gy and received HIFU treatment 3 times in average,and were observed therapeutic effects including clinical benefit response,tumorous objective evaluation,the concentration of several tumor markers.That is to utilize chemoimmunity analyticalmethod to detect carbohydrate antigen 19-9（CA19-9）,carcino-embryonic antigen（CEA）.Results There were 20 clinical benefit response among 35 pancreatic carcinoma patients received HIFU.The clinical benefit response rate was 65.71%.The concentration variability of CA19-9,CEA was significant before and after the treatment.The treatment cases were well in the observation group.The complicated symptoms did not perform after the treat...更多ment.Conclusion HIFU combined with radiation in treating pancreatic carcinoma can control the progress of tumor,improve the quality of life,and prolong overall survival.It also can reduce the levels of CA19-9 and CEA.Furthermore,no significant adverse reaction occurres in the treatment.
出处
《重庆医学》
CAS
CSCD
北大核心
2010年第3期283-284,287,共3页
Chongqing medicine
关键词
高强度聚焦超声
局部放疗
胰腺癌
High intensity focused ultrasound
Radiation
Pancreatic carcinoma
