摘要
目的通过测定急、慢性乙型病毒性肝炎患者血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)水平变化,探讨其对急慢性肝炎诊断、预后判断的价值。方法对临床确诊的急、慢性乙型肝炎患者共144例检测血清TNF-α、IL-6及IL-8的水平。结果急、慢性乙型病毒性肝炎患者体内TNF-α、IL-6、IL-8水平均明显高于正常对照组,急性乙型病毒性肝炎患者TNF-α、IL-6、IL-8水平低于慢性乙型病毒性肝炎患者,具有统计学意义统计学意义(P<0.05)。结论TNF-α、IL-6、IL-8参与急慢性乙型肝炎的病理过程,其血清水平与急慢性乙型肝炎患者肝细胞受损程度有关,动态测定血清TNF-α、IL-6、IL-8水平有利于监视病情。
Objective By measuring the levels of serum TNF-α、IL-6 and IL-8 in the acute and chronic hepatitis B patients to explore its diagnosis and prognosis value for acute and chronic hepatitis.Methods 144 cases of clinical acute and chronic hepatitis B patients were detected in the levels of serum TNF-α、IL-6 and IL-8.Results The levels of TNF-α、IL-6 and IL-8 in acute and chronic hepatitis B patients were significantly higher than the normal control group.The levels of TNF-α、IL-6 and IL-8 in acute hepatitis B patients are lower than the chronic hepatitis B patients.They have statistical significance（P〈0.05）.Conclusion TNF-α、IL-6 and IL-8 involved in the pathological process of acute and chronic hepatitis B.The serum levels of them are related to the degree of liver cell damage in acute and chronic hepatitis B patients.Dynamic measurement to the levels of serum TNF-α,IL-6 and IL-8 is conducive to disease surveillance.
出处
《医学综述》
2010年第4期638-639,共2页
Medical Recapitulate
