摘要
对FeCl3作用下各种炔醇与碘的反应进行了详细研究,结果表明在FeCl3和碘的作用下,炔醇发生分子内碘代环化反应生成碘代环烯醚,产率为63%～90%.在相同的反应条件下,炔丙醇类则生成邻二碘化物,产率为15%～88%.该反应具有操作简单、底物适应广、反应快(3h)和碘用量(0.5equiv.)少等特点,是制备碘代环烯醚和2,3-二碘代烯醇的好方法.
The FeCl3-mediated reaction of alkynols with iodine resulted in intramolecular addition of hydroxyl to alkyne to produce a wide range of iodocycloenol ethers in good to excellent yields （63%-90%） under mild reaction conditions. On the other hand, 1,2-diiodides were obtained generally in good yields （15%-88%） when propargyl alcohols were reacted with iodine in the same condition. The advantages of our procedure include a decreased amount of iodine （0.5 equiv.） as well as short reaction time （3 h）. The broad scope, mild reaction conditions, and experimental ease of this transformation have made it a valuable alternative to current available methods for the preparation of iodocycloenol ethers or 2,3-diiodoalkenols.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2010年第2期266-271,共6页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20772099)资助项目
