摘要
目的对比分析肩胛舌骨上颈淋巴清扫术(supraomohyoid neck dissection,SOND)和传统根治性颈淋巴清扫术(classical radical neck dissection,CRND)对口腔鳞状细胞癌cN0期患者术后颈部复发率、生存率和生存质量的影响。方法68例临床cN0期的口腔鳞癌患者随机分为2组:CRND组和SOND组均为34例。统计比较术后颈部复发率,应用SPSS10.0软件统计分析2组患者术后3年、5年生存率,用华盛顿大学生存质量问卷评价两组患者的生存质量。结果CRND组和SOND组3年颈部复发率分别为8.8%、11.7%,5年颈部复发率分别为11.8%、14.7%;CRND组和SOND组3年生存率分别为69.1%、68.4%,5年生存率分别为55.6%、54.9%;CRND组和SOND组生存质量平均总分各为533.57±112.22,653.06±84.92,有统计学差异。因而对cN0期的口腔鳞癌患者行肩胛舌骨上颈淋巴清扫术与传统根治性颈淋巴清扫术相比,没有降低患者术后生存率和颈部复发率,但显著地提高了患者术后的生存质量。结论肩胛舌骨上颈淋巴清扫术在cN0期口腔鳞癌患者的治疗上可以取代传统根治性颈淋巴清扫术。
Objective To investigate the effects of classical radical neck dissection （CRND）and supraomohyoid neck dissection （SOND） on neck recurrence rate,survival rate and quality of life （QOL） of the patients with oral squamous cell carcinoma （OSCC） in cN0 stage. Methods 68 patients in cN0 stage of. OSCC were divided randomly into two groups： group CRND （34 cases） and group SOND（34 cases）. Neck recurrence rates between two groups were compared. Survival rates of 3-year and 5-year were analyzed by SPSS10. 0 statistic software. UW-QOL questionnaire was used to evaluate QOL of different groups. Results （1）3-year neck recurrence rates of group CRND and group SOND were 8. 8%, 11.7%, respectively（ P 〉 0. 05 ）, and 5-year neck recurrence rates were 11.8%, 14. 7% ,respectively（P 〉 0. 05 ）. （2）3-year survival rate of group CRND and group SOND were 69. 1%, 68.4%, respectively（P 〉 0. 05）,and 5-year survival rates were 55.6% ,54. 9% ,respectively（P 〉0. 05）. （3）Average total scores of QOL of group CRND and group SOND were 533.57 ± 112. 22,653.06 ± 84. 92, respectively（P 〈 0.05 ）. Compared with CRND, SOND does not decrease survival rate of OSCC, while it can improve the quality of life for oral cancer patients in cN0 stage. Conclusion SOND can replace the CRND for patients with oral squamous cell carcinoma in cN0 stage.
出处
《口腔医学》
CAS
2010年第2期98-100,共3页
Stomatology
关键词
颈淋巴清扫术
口腔
鳞状细胞癌
生存率
生存质量
neck dissection
oral
squamous cell carcinoma
survival rate
quality of life
