摘要
目的对载药纳米仿生骨治疗骨缺损伴骨髓炎的研究进展进行综述，为相关研究提供理论基础与实验参考。方法查阅国内外相关文献，对载药纳米仿生骨治疗骨缺损与骨髓炎的研究现状进行分析。综述载药纳米仿生骨的设计与制备方法，骨缺损与骨髓炎动物模型的制作以及该研究的大体步骤、检测指标与效果评价。结果创伤性骨髓炎与骨缺损是临床骨科难以治疗的两大疾病，许多研究者使用纳米级材料制作仿生骨，并通过不同方法在其中加入药物，以期同时治疗感染并修复骨缺损，但研究总体仍处于实验室阶段，且缺乏相关动物模型的制作标准，在药物缓释及仿生骨制备方法上还需进一步改良。结论载药纳米仿生骨在多项治疗动物骨髓炎与骨缺损的研究中均取得了较好的效果，有望作为一种新兴的骨替代材料。
Objective To review the research progress in the treament of bone defect or osteomyelitis with drug-carried bionic nano-bone so as to offer some theoretic supports and experimental references for those relative researchers. Methods The related literature was reviewed. The research progress in the treatment of bone defect or osteomyelitis with drug-carried bionic nano-bone was analyzed, which included the designing and preparing of drug-carried nano composites, the way of making infected bone defect animal models, and the general steps, test indexes and results. Results Traumatic osteomyelitis and bone defect were two kinds of disease to difficultly cure in nowadays clinical orthopaedics. The osteomyelitis, especially chronic one was quite troublesome during the treatments. Many researchers made artifical bone with nano-materials and added drugs into them by various ways for the purpose of controlling infection and repairing bone defection simultaneously. But these researches were still at the laboratory phase, lacking the criterions of making relative animal models, and needed to be improved in the way of drug slow-releasing and nano-scaffold producing. Conclusion The drug-carried bionic nano-bone as a kind of newly emerging replacement material has splendid effects in the treatments of traumatic large area bone defect or osteomyelitis and will have a brilliant future.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2010年第3期356-362,共7页
Chinese Journal of Reparative and Reconstructive Surgery
关键词
载药纳米仿生骨
骨缺损
骨髓炎
Drug-carried bionic nano-bone Bone defect Osteomyel iris
