摘要
目的:探讨CD44s和ESA在胰腺癌组织中表达及其与临床病理特征的关系。方法:应用免疫组化SP法检测20例癌旁组织和50例胰腺癌组织中CD44s和ESA的表达。结果:CD44s和ESA在胰腺癌中的表达明显高于癌旁正常组织中的表达,CD44s的表达与淋巴结转移和病理分级有关(P<0.05);而ESA的表达仅与病理分级有关(P<0.05);两者之间表达呈正相关(P=0.017,rs=5.747)。结论:CD44s和ESA在胰腺的发生发展、浸润转移中密切相关,发挥重要作用,两者可作为胰腺癌浸润、转移及评估预后的指标。
Objective:To investigate the expressions of CD44s and ESA and the relationship between their expressions and clinicopathological characteristics in pancreatic carcinoma. Methods:Expressions of CD44s and ESA in 20 cases of pancreatic paraneoplastic tissues and 50 cases of pancreatic carcinoma were detected by immunohistocbemical method. Results:The expressions of CD44s and ESA in pancreatic carcinoma were significantly higher than in pancreatic paraneoplastic tissues. Significant relationship was found among the expression of CD44s and lymphatica metastasis, pathological grade ( P 〈 0.05 ). The expression of ESA was correlated with pathological grade ( P 〈 0.05 ). There was a positive correlation between the expressions of ESA and CD44s (P = 0.017, rs = 5. 747 ). Conclusion:The expressions of ESA and CD44s were highly related to occurrence, development, infiltration and metastasis of pancreatic carcinoma. Both of them might play an important role in the progression of human pancreatic carcinomas and participate in the invasion and metastasis of pancreatic carcinoma.
出处
《现代肿瘤医学》
CAS
2010年第3期520-522,共3页
Journal of Modern Oncology