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弹簧式液体喷射注射过程的建模及实验研究 被引量：7

Modeling and Experimental Study of Spring-driven Liquid Jet Injection Process
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摘要 液体喷射注射器是一种利用高速药物射流对人体进行药物和疫苗注射的注射系统。影响注射器注射质量的系统参数包括喷孔直径、药物注射剂量、安瓿直径、推射压力和冲撞距离等。针对以弹簧为驱动力的液体喷射注射系统,提出一种计算喷射压强的模型。根据该模型计算给定系统参数时喷射压强随时间变化的动态关系和最大喷射滞止压强。计算结果与在相同系统参数下实验测得的动态喷射压强相吻合;不同剂量、不同弹簧系数情况下计算的最大喷射滞止压强亦与实验结果相一致。实验结果验证了所建模型的正确性和有效性。
作者 陈凯 周华
机构地区 杭州电子科技大学机械工程学院
出处 《中国生物医学工程学报》 CAS CSCD 北大核心 2010年第1期150-154,共5页 Chinese Journal of Biomedical Engineering
基金 国家自然科学基金资助项目(50775059)
关键词 无针注射 喷射 模型 滞止压强 liquid needle-free injection jet modeling stagnation pressure
分类号 TH11 [机械工程—机械设计及理论] R318.08 [医药卫生—生物医学工程]
  • 相关文献

参考文献6

  • 1Mitragotri S. Current status and future prospects of needle-free liquid jet injectors[ J]. Nature Reviews, Drug Discovery, 2006, 5 : 543 - 548.
  • 2Schramm-Baxter J, Katrencik J, Mitragotri S. Needle-free jet injections: dependence of jet penetration and dispersion in the skin on jet power[ J]. Journal of Control Release, 2004, 97: 527 - 535.
  • 3Shergold OA, Fleck NA, King TS. The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection [ J ]. Journal of Biomechanics, 2006, 39 (14) : 2593 -2602.
  • 4Baker AB, Sanders JE. Fluid mechanics analysis of a spring- loaded jet injector [ J ]. IEEE Trans Biomed Eng, 1999, 46 (2) : 235 -242.
  • 5广庭洪,汪德涛.密封件使用手册[M].北京:机械工业出版社,1994.
  • 6周华,陈凯,吕永桂.一种液体喷射注射系统的设计与检测[J].机械设计与研究,2009,25(2):116-120. 被引量：4

二级参考文献9

  • 1Mitragotri S. Immunization without needles[ J]. Nature REV. Immunal, 2005,5:905-916.
  • 2Suzuki T, Takahashi I. & Takada G. Daily subcutaneous erythropoictin by jet injection in pediatric dialysis patients[J]. Nephron, 1995,69:347.
  • 3Brodell R T and Bredle D L. The treatment of palmar and plantar warts using natural a-interferon and a needleless injector[ J]. Dermatol Surg, 1995,21:213 -218.
  • 4Mitragotri S. Current status and future prospects of needle-free liquid jet injectors [ J ]. Nature Reviews, Drug Discovery, 2006,5:543 - 548.
  • 5Schramm - Baxter J, Mitragotri S. Needle - free jet injections:dependence of jet penetration and dispersion in the skin on jet power [ J]. Journal of Control Release,2004,97:527 - 535.
  • 6Schramm-Baxter J, Katrencik J, Mitragotri S. Jet injection into polyacrylamide gels: investigation of jet injection mechanics [ J ]. Journal of Biomechanics ,2004,37 : 1181 - 1188.
  • 7Shergold O A, Fleck N A, King T S. The penetration of a soft solid by a liquid jet,with application to the administration of a needlefree injection [ J]. Journal of Biomechanics, 2006, 39:2593 - 2602.
  • 8Shergold O A and Fleck N A. Mechanisms of deep penetration of soft solids, with application to the injection and wounding of skin [ C ]//Proceedings of the Royal Society of London. Series B, Biological Sciences, 2004,460 : 3037 - 3058.
  • 9Schramm-Baxter J. and Mitragotri S. Jet-induced skin puncture and its impact on needle-free jet injections: experimental studies and a predictive model [ J]. Journal of Control. Release, 2005, 106:361 - 373.

共引文献3

同被引文献63

  • 1Willson P. Novel Vaccine Delivery Technology[J]. Advances in Pork Production, 2005,16 : 219-224.
  • 2Chase C C L,Daniels C S,Garcia R,et al. Needle-free Injection Technology in Swine: Progress To- ward Vaccine Efficacy and Pork Quality [J].J. Swine Health Production,2008,16(5) :254-261.
  • 3Houser T A,Sebranek J G,Thacker B J ,et al. Effectiveness of Transdermal, Needle-- free Injections for Reducing Pork Carcass Defects[J]. J. Meat Science, 2004,68:329-332.
  • 4Shergold O A, Fleck N A, King T S. The Penetration of a Soft Solid by a Liquid Jet,with Application to the Administration of a Needle--free Injection [J]. Journal of Biomechanics,2006,39:2593-2602.
  • 5Mitragotri S. Current Status and Future Prospects of Needle--free Liquid Jet Injectors[J]. Nature Reviews, Drug Discovery, 2006,5 : 543-548.
  • 6Sehramm-- Baxter J, Mitragotri S. Needle-- free Jet Injections: Dependence of Jet Penetration and Dispersion in the Skin on Jet Power[J]. Journal of Control Release, 2004,97 : 527-535.
  • 7Baker A B,Sanders J E. Fluid Mechanics Analysis of a Spring-loaded Jet Injector[J]. IEEE Trans. Biomed Eng. ,1999,46(2) :235-242.
  • 8Mitragotri S. Current status and future prospects of needle-free liquid jet injectors[ J]. Nature Reviews, Drug Discovery, 2006, 5: 543-548.
  • 9King T. A review of needle-free injection technologies[ R]. The Drug Delivery Companies Report Spring 2002, PharmaVentures Ltd, 2002.
  • 10Shergold OA, Fleck NA, King TS. The penetration of a soft solid by a liquid jet, with application to the administration of a needle-free injection [ J ]. Journal of Biomechanics, 2006, 39 : 2593 - 2602.

引证文献7

二级引证文献13

中国生物医学工程学报
2010年 第1期

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