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真核翻译起始因子3与肿瘤 被引量：3

Eukaryotic Translation Initiation Factor 3 and Tumor
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摘要 真核翻译起始因子3是由多个亚基组成的，在真核翻译起始中发挥重要作用，近年来的研究表明其多个亚基在多种肿瘤细胞中存在异常表达的现象且与肿瘤的侵袭性、转移能力、分化程度及预后相关，使其有望成为肿瘤治疗的新靶点。 The eukaryotic translation initiation factor 3 （eIF-3） complex consists of multiple subunits and plays an important role in eukaryotic translation initiation. It has been found in recent years that, various subunits of eIF3 are abnormally express in tumors, which is closely related to tumor invasiveness, metastasis, differentiation, and prognosis of cancer. Therefore, cIF-3 may be hopeful as a potential anti-cancer therapeutic target.
作者 褚丽莎(综述) 宋向阳 曹江(审阅)
机构地区 浙江大学附属邵逸夫医院肿瘤外科 浙江大学邵逸夫临床医学研究所
出处 《医学分子生物学杂志》 CAS CSCD 2010年第1期86-89,共4页 Journal of Medical Molecular Biology
基金 浙江省自然科学基金（No.Y207104）
关键词 真核翻译起始因子3 肿瘤 表达 eukaryotic translation initiation factor 3 tumor expression
分类号 R730.231 [医药卫生—肿瘤]
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共引文献13

同被引文献56

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医学分子生物学杂志
2010年 第1期

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